Format

Send to:

Choose Destination

SORBS1 sorbin and SH3 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 10580, updated on 11-Sep-2019

Summary

Official Symbol
SORBS1provided by HGNC
Official Full Name
sorbin and SH3 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:14565
See related
Ensembl:ENSG00000095637 MIM:605264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12
Summary
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in fat (RPKM 111.7), heart (RPKM 81.6) and 15 other tissues See more
Orthologs

Genomic context

See SORBS1 in Genome Data Viewer
Location:
10q24.1
Exon count:
36
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (95311773..95561439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97071530..97321171, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 568 Neighboring gene PDZ and LIM domain 1 Neighboring gene Sharpr-MPRA regulatory region 12220 Neighboring gene VISTA enhancer hs2353 Neighboring gene ribosomal protein S3a pseudogene 36 Neighboring gene aldehyde dehydrogenase 18 family member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of suicide attempts in mood disorder patients.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of sorbin and SH3 domain containing 1 (SORBS1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12406, KIAA1296, DKFZp451C066, DKFZp586P1422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3/SH2 adaptor activity IC
Inferred by Curator
more info
PubMed 
SH3/SH2 adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
actin binding TAS
Traceable Author Statement
more info
PubMed 
cytoskeletal protein binding TAS
Traceable Author Statement
more info
PubMed 
insulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle contraction TAS
Traceable Author Statement
more info
 
positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell-cell adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-substrate adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
colocalizes_with insulin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
 
zonula adherens TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sorbin and SH3 domain-containing protein 1
Names
Fas-ligand associated factor 2
SH3 domain protein 5
c-Cbl associated protein
ponsin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034041.1 RefSeqGene

    Range
    5001..254648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001034954.1NP_001030126.1  sorbin and SH3 domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001030126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also named M1, encodes the longest protein (isoform 3).
    Source sequence(s)
    AF330623, AF356525, AL117472, AL158165, BC042612
    Consensus CDS
    CCDS31255.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000355136.3, ENST00000361941.7
    Conserved Domains (4) summary
    cd11916
    Location:12331291
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:796850
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:870927
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:370408
    Sorb; Sorbin homologous domain
  2. NM_001034955.1NP_001030127.1  sorbin and SH3 domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001030127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also named M2, has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 4 which is shorter than isoform 3.
    Source sequence(s)
    AF330623, AF356526, AL117472, AL158165, BC042612
    Consensus CDS
    CCDS31254.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000277982.5, ENST00000277982.9
    Conserved Domains (4) summary
    cd11916
    Location:10921150
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:818872
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:892949
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:370408
    Sorb; Sorbin homologous domain
  3. NM_001034956.1NP_001030128.1  sorbin and SH3 domain-containing protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001030128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also named M8, has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 5 which is shorter than isoform 3.
    Source sequence(s)
    AF330623, AF356527, AL117472, BC042612
    Consensus CDS
    CCDS31256.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000360291.2, ENST00000371245.7
    Conserved Domains (4) summary
    cd11916
    Location:846904
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:647701
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:721778
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:301342
    Sorb; Sorbin homologous domain
  4. NM_001034957.1NP_001030129.1  sorbin and SH3 domain-containing protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001030129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also designated as variants A2, L3 and M11, has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 7 which is shorter than isoform 3.
    Source sequence(s)
    AB037717, AF136380, AL117472, BC042612
    UniProtKB/Swiss-Prot
    Q9BX66
    Conserved Domains (4) summary
    cd11916
    Location:681739
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:502556
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:576633
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:206247
    Sorb; Sorbin homologous domain
  5. NM_001290294.2NP_001277223.2  sorbin and SH3 domain-containing protein 1 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 8) is shorter than isoform 3.
    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS73169.1
    Related
    ENSP00000360271.3, ENST00000371227.8
  6. NM_001290295.2NP_001277224.2  sorbin and SH3 domain-containing protein 1 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 9) is shorter than isoform 3.
    Source sequence(s)
    AL157890, AL158165
  7. NM_001290296.1NP_001277225.1  sorbin and SH3 domain-containing protein 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 10) is shorter than isoform 3.
    Source sequence(s)
    AF136381, AF330623, AF356525, AL117472, BC152463
    Consensus CDS
    CCDS76327.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000277984.4, ENST00000354106.7
    Conserved Domains (4) summary
    cd11916
    Location:9451003
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:766820
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:840897
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:361399
    Sorb; Sorbin homologous domain
  8. NM_001290297.1NP_001277226.1  sorbin and SH3 domain-containing protein 1 isoform 11

    See identical proteins and their annotated locations for NP_001277226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 11) is shorter than isoform 3.
    Source sequence(s)
    AF330623, AL117472, BC152463
    Consensus CDS
    CCDS76326.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000360283.1, ENST00000371239.5
    Conserved Domains (4) summary
    cd11916
    Location:752810
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:573627
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:647704
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:215256
    Sorb; Sorbin homologous domain
  9. NM_001290298.1NP_001277227.1  sorbin and SH3 domain-containing protein 1 isoform 12

    See identical proteins and their annotated locations for NP_001277227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. The encoded protein (isoform 12) is shorter than isoform 3.
    Source sequence(s)
    AJ489942, AL117472, BC152463
    UniProtKB/Swiss-Prot
    Q9BX66
    Conserved Domains (4) summary
    cd11916
    Location:787845
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:608662
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:682739
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:238276
    Sorb; Sorbin homologous domain
  10. NM_006434.2NP_006425.2  sorbin and SH3 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006425.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 1 which is shorter than isoform 3.
    Source sequence(s)
    AB037717, AF136380, AL117472, BC042612
    Consensus CDS
    CCDS31252.1
    UniProtKB/Swiss-Prot
    Q9BX66
    Related
    ENSP00000360285.1, ENST00000371241.5
    Conserved Domains (4) summary
    cd11916
    Location:625683
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:446500
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:520577
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:206247
    Sorb; Sorbin homologous domain
  11. NM_015385.4NP_056200.2  sorbin and SH3 domain-containing protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 2 which is shorter than isoform 3.
    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS7442.1
    Related
    ENSP00000360295.2, ENST00000371249.6
  12. NM_024991.3NP_079267.2  sorbin and SH3 domain-containing protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 6 which is shorter than isoform 3.
    Source sequence(s)
    AL157890, AL158165
    Consensus CDS
    CCDS31253.1
    Related
    ENSP00000302556.6, ENST00000306402.10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    95311773..95561439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015526.2XP_016871015.1  sorbin and SH3 domain-containing protein 1 isoform X33

  2. XM_017015508.2XP_016870997.1  sorbin and SH3 domain-containing protein 1 isoform X15

  3. XM_017015506.2XP_016870995.1  sorbin and SH3 domain-containing protein 1 isoform X12

  4. XM_017015511.2XP_016871000.1  sorbin and SH3 domain-containing protein 1 isoform X18

  5. XM_017015504.2XP_016870993.1  sorbin and SH3 domain-containing protein 1 isoform X10

  6. XM_024447770.1XP_024303538.1  sorbin and SH3 domain-containing protein 1 isoform X8

    Conserved Domains (4) summary
    cd11916
    Location:11231181
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:666720
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:740797
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:370411
    Sorb; Sorbin homologous domain
  7. XM_024447769.1XP_024303537.1  sorbin and SH3 domain-containing protein 1 isoform X5

    Conserved Domains (4) summary
    cd11916
    Location:12321290
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:775829
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:849906
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:370408
    Sorb; Sorbin homologous domain
  8. XM_017015510.2XP_016870999.1  sorbin and SH3 domain-containing protein 1 isoform X17

  9. XM_017015500.2XP_016870989.1  sorbin and SH3 domain-containing protein 1 isoform X4

  10. XM_017015505.2XP_016870994.1  sorbin and SH3 domain-containing protein 1 isoform X11

  11. XM_017015503.2XP_016870992.1  sorbin and SH3 domain-containing protein 1 isoform X9

  12. XM_017015501.2XP_016870990.1  sorbin and SH3 domain-containing protein 1 isoform X6

  13. XM_011539150.2XP_011537452.1  sorbin and SH3 domain-containing protein 1 isoform X2

    Conserved Domains (4) summary
    cd11916
    Location:14461504
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:9891043
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:10631120
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:609650
    Sorb; Sorbin homologous domain
  14. XM_017015507.2XP_016870996.1  sorbin and SH3 domain-containing protein 1 isoform X14

  15. XM_017015502.2XP_016870991.1  sorbin and SH3 domain-containing protein 1 isoform X7

  16. XM_011539140.2XP_011537442.1  sorbin and SH3 domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    cd11916
    Location:14711529
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:10141068
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:10881145
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:609647
    Sorb; Sorbin homologous domain
  17. XM_017015537.2XP_016871026.1  sorbin and SH3 domain-containing protein 1 isoform X44

  18. XM_017015532.2XP_016871021.1  sorbin and SH3 domain-containing protein 1 isoform X39

  19. XM_017015528.2XP_016871017.1  sorbin and SH3 domain-containing protein 1 isoform X35

  20. XM_017015522.2XP_016871011.1  sorbin and SH3 domain-containing protein 1 isoform X29

  21. XM_017015516.2XP_016871005.1  sorbin and SH3 domain-containing protein 1 isoform X24

  22. XM_006717589.2XP_006717652.1  sorbin and SH3 domain-containing protein 1 isoform X22

    UniProtKB/Swiss-Prot
    Q9BX66
    Conserved Domains (4) summary
    cd11916
    Location:9451003
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:766820
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:840897
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cl02617
    Location:361399
    Sorb; Sorbin homologous domain
  23. XM_017015529.2XP_016871018.1  sorbin and SH3 domain-containing protein 1 isoform X36

  24. XM_017015530.2XP_016871019.1  sorbin and SH3 domain-containing protein 1 isoform X37

  25. XM_017015534.2XP_016871023.1  sorbin and SH3 domain-containing protein 1 isoform X41

  26. XM_017015520.2XP_016871009.1  sorbin and SH3 domain-containing protein 1 isoform X27

  27. XM_017015517.2XP_016871006.1  sorbin and SH3 domain-containing protein 1 isoform X25

  28. XM_017015515.2XP_016871004.1  sorbin and SH3 domain-containing protein 1 isoform X23

  29. XM_006717593.1XP_006717656.1  sorbin and SH3 domain-containing protein 1 isoform X47

    Conserved Domains (4) summary
    cd11916
    Location:681739
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:502556
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:576633
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:206247
    Sorb; Sorbin homologous domain
  30. XM_017015539.1XP_016871028.1  sorbin and SH3 domain-containing protein 1 isoform X45

  31. XM_017015512.1XP_016871001.1  sorbin and SH3 domain-containing protein 1 isoform X19

  32. XM_017015540.1XP_016871029.1  sorbin and SH3 domain-containing protein 1 isoform X46

  33. XM_017015513.1XP_016871002.1  sorbin and SH3 domain-containing protein 1 isoform X20

  34. XM_017015514.1XP_016871003.1  sorbin and SH3 domain-containing protein 1 isoform X21

  35. XM_017015533.1XP_016871022.1  sorbin and SH3 domain-containing protein 1 isoform X40

  36. XM_017015524.1XP_016871013.1  sorbin and SH3 domain-containing protein 1 isoform X31

  37. XM_011539167.1XP_011537469.1  sorbin and SH3 domain-containing protein 1 isoform X13

    Conserved Domains (4) summary
    cd11916
    Location:10821140
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:625679
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:699756
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:329370
    Sorb; Sorbin homologous domain
  38. XM_011539155.1XP_011537457.1  sorbin and SH3 domain-containing protein 1 isoform X3

    Conserved Domains (4) summary
    cd11916
    Location:13211379
    SH3_Sorbs1_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11919
    Location:864918
    SH3_Sorbs1_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    cd11922
    Location:938995
    SH3_Sorbs1_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 1 (Sorbs1), also called ponsin
    pfam02208
    Location:568609
    Sorb; Sorbin homologous domain
  39. XM_017015535.1XP_016871024.1  sorbin and SH3 domain-containing protein 1 isoform X42

  40. XM_017015527.1XP_016871016.1  sorbin and SH3 domain-containing protein 1 isoform X34

  41. XM_017015509.1XP_016870998.1  sorbin and SH3 domain-containing protein 1 isoform X16

  42. XM_017015536.1XP_016871025.1  sorbin and SH3 domain-containing protein 1 isoform X43

  43. XM_017015531.1XP_016871020.1  sorbin and SH3 domain-containing protein 1 isoform X38

  44. XM_017015525.1XP_016871014.1  sorbin and SH3 domain-containing protein 1 isoform X32

  45. XM_017015523.1XP_016871012.1  sorbin and SH3 domain-containing protein 1 isoform X30

  46. XM_017015521.1XP_016871010.1  sorbin and SH3 domain-containing protein 1 isoform X28

  47. XM_017015518.1XP_016871007.1  sorbin and SH3 domain-containing protein 1 isoform X26

Support Center