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TACC2 transforming acidic coiled-coil containing protein 2 [ Homo sapiens (human) ]

Gene ID: 10579, updated on 7-Jun-2020

Summary

Official Symbol
TACC2provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 2provided by HGNC
Primary source
HGNC:HGNC:11523
See related
Ensembl:ENSG00000138162 MIM:605302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZU-1; ECTACC
Summary
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues See more
Orthologs

Genomic context

See TACC2 in Genome Data Viewer
Location:
10q26.13
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (121989163..122254542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123748689..124014057)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arginyltransferase 1 Neighboring gene ATE1 antisense RNA 1 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354 Neighboring gene Sharpr-MPRA regulatory regions 1076 and 11287 Neighboring gene BTB domain containing 16 Neighboring gene RNA, U6 small nuclear 728, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 2
Names
anti zuai-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029948.2 RefSeqGene

    Range
    5001..270372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291876.2NP_001278805.2  transforming acidic coiled-coil-containing protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several internal exons in the CDS compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS76348.1
    Related
    ENSP00000427618.1, ENST00000515603.5
  2. NM_001291877.2NP_001278806.2  transforming acidic coiled-coil-containing protein 2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks several internal exons and uses an alternate splice site in the CDS compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS76349.1
    Related
    ENSP00000424467.1, ENST00000515273.5
  3. NM_001291878.2NP_001278807.1  transforming acidic coiled-coil-containing protein 2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate structure in the 5' UTR and 5' coding region and lacks an internal exon compared to variant 1. The encoded isoform (g) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL135793, BC039311, BC141837, R46074
    Consensus CDS
    CCDS76351.1
    UniProtKB/Swiss-Prot
    O95359
    UniProtKB/TrEMBL
    D6RAA5
    Related
    ENSP00000422815.1, ENST00000369004.7
    Conserved Domains (3) summary
    pfam05010
    Location:8021002
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:9211001
    FadA; Adhesion protein FadA
    cl23765
    Location:821923
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001291879.2NP_001278808.1  transforming acidic coiled-coil-containing protein 2 isoform h

    See identical proteins and their annotated locations for NP_001278808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region and lacks two internal coding exons compared to variant 1. These differences result in the use of a downstream AUG compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC063960, AL135793, BC015736, R46074
    Consensus CDS
    CCDS76352.1
    UniProtKB/TrEMBL
    Q4VXL4
    Related
    ENSP00000357997.1, ENST00000369001.5
    Conserved Domains (1) summary
    pfam05010
    Location:369569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  5. NM_006997.4NP_008928.1  transforming acidic coiled-coil-containing protein 2 isoform d

    See identical proteins and their annotated locations for NP_008928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a different structure for its 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF095791, AL135793, BC039311, R46074
    Consensus CDS
    CCDS7627.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000260733.3, ENST00000260733.7
    Conserved Domains (2) summary
    pfam05010
    Location:8201020
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:9391019
    FadA; Adhesion protein FadA
  6. NM_206860.3NP_996742.1  transforming acidic coiled-coil-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_996742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different structure for its 5' UTR and 5' coding region, and also lacks an internal coding exon compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL135793, BC039311, R46074
    Consensus CDS
    CCDS7628.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000353763.3, ENST00000360561.7
    Conserved Domains (3) summary
    pfam05010
    Location:790990
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:909989
    FadA; Adhesion protein FadA
    cl11495
    Location:785917
    IncFII_repA; IncFII RepA protein family
  7. NM_206861.3NP_996743.1  transforming acidic coiled-coil-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_996743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three internal in-frame exons compared to variant 1. The resulting protein (isoform b) is shorter compared to isoform a. Isoform b has also been called the 'short' isoform
    Source sequence(s)
    AF528098, AL135793, AL731566, R46074
    Consensus CDS
    CCDS7625.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000425062.1, ENST00000513429.5
    Conserved Domains (2) summary
    pfam05010
    Location:8881088
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:10071087
    FadA; Adhesion protein FadA
  8. NM_206862.4NP_996744.4  transforming acidic coiled-coil-containing protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Isoform a has also been called the 'long' isoform.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS7626.1
    Related
    ENSP00000358001.1, ENST00000369005.6
    Conserved Domains (2) summary
    pfam05010
    Location:27422942
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl26464
    Location:15468
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    121989163..122254542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447756.1XP_024303524.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    Conserved Domains (3) summary
    pfam05010
    Location:28053005
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21852572
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24488
    Atrophin-1; Atrophin-1 family
  2. XM_005269390.1XP_005269447.1  transforming acidic coiled-coil-containing protein 2 isoform X6

    Conserved Domains (3) summary
    pfam05010
    Location:27742974
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28932973
    FadA; Adhesion protein FadA
    pfam13863
    Location:27782879
    DUF4200; Domain of unknown function (DUF4200)
  3. XM_017015485.1XP_016870974.1  transforming acidic coiled-coil-containing protein 2 isoform X12

  4. XM_006717552.1XP_006717615.1  transforming acidic coiled-coil-containing protein 2 isoform X17

    Conserved Domains (3) summary
    pfam05010
    Location:26972897
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28162896
    FadA; Adhesion protein FadA
    cl02488
    Location:27362899
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  5. XM_005269388.1XP_005269445.1  transforming acidic coiled-coil-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005269445.1

    Conserved Domains (3) summary
    pfam05010
    Location:27932993
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:29122992
    FadA; Adhesion protein FadA
    pfam13863
    Location:27972898
    DUF4200; Domain of unknown function (DUF4200)
  6. XM_005269392.1XP_005269449.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    Conserved Domains (3) summary
    pfam05010
    Location:27632963
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28822962
    FadA; Adhesion protein FadA
    cl02488
    Location:28022965
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_005269396.1XP_005269453.1  transforming acidic coiled-coil-containing protein 2 isoform X16

    Conserved Domains (3) summary
    pfam05010
    Location:27162916
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28352915
    FadA; Adhesion protein FadA
    cl02488
    Location:27552918
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. XM_005269393.1XP_005269450.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    Conserved Domains (3) summary
    pfam05010
    Location:27622962
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28812961
    FadA; Adhesion protein FadA
    pfam13863
    Location:27662867
    DUF4200; Domain of unknown function (DUF4200)
  9. XM_017015486.1XP_016870975.1  transforming acidic coiled-coil-containing protein 2 isoform X13

  10. XM_006717553.1XP_006717616.1  transforming acidic coiled-coil-containing protein 2 isoform X18

    Conserved Domains (3) summary
    pfam05010
    Location:26852885
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28042884
    FadA; Adhesion protein FadA
    cl02488
    Location:27242887
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  11. XM_017015484.1XP_016870973.1  transforming acidic coiled-coil-containing protein 2 isoform X4

  12. XM_006717548.1XP_006717611.1  transforming acidic coiled-coil-containing protein 2 isoform X11

    Conserved Domains (3) summary
    pfam05010
    Location:27582958
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28772957
    FadA; Adhesion protein FadA
    pfam13863
    Location:27622863
    DUF4200; Domain of unknown function (DUF4200)
  13. XM_017015487.1XP_016870976.1  transforming acidic coiled-coil-containing protein 2 isoform X14

  14. XM_006717554.1XP_006717617.1  transforming acidic coiled-coil-containing protein 2 isoform X19

    Conserved Domains (3) summary
    pfam05010
    Location:26812881
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:28002880
    FadA; Adhesion protein FadA
    cl02488
    Location:27202883
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  15. XM_024447761.1XP_024303529.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    Conserved Domains (3) summary
    pfam05010
    Location:27602960
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21402527
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24488
    Atrophin-1; Atrophin-1 family
  16. XM_005269399.1XP_005269456.1  transforming acidic coiled-coil-containing protein 2 isoform X22

    Conserved Domains (3) summary
    pfam05010
    Location:26402840
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:27592839
    FadA; Adhesion protein FadA
    pfam13863
    Location:26442745
    DUF4200; Domain of unknown function (DUF4200)
  17. XM_024447760.1XP_024303528.1  transforming acidic coiled-coil-containing protein 2 isoform X8

    Conserved Domains (4) summary
    pfam05010
    Location:27632963
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21432530
    DUF4045; Domain of unknown function (DUF4045)
    cl26386
    Location:15261987
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:24488
    Atrophin-1; Atrophin-1 family
  18. XM_024447762.1XP_024303530.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    Conserved Domains (3) summary
    pfam05010
    Location:27182918
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:20982485
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24488
    Atrophin-1; Atrophin-1 family
  19. XM_017015489.1XP_016870978.1  transforming acidic coiled-coil-containing protein 2 isoform X21

  20. XM_017015488.1XP_016870977.1  transforming acidic coiled-coil-containing protein 2 isoform X20

  21. XM_024447763.1XP_024303531.1  transforming acidic coiled-coil-containing protein 2 isoform X24

    Conserved Domains (3) summary
    pfam05010
    Location:9961196
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:376763
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24222
    Atrophin-1; Atrophin-1 family
  22. XM_024447764.1XP_024303532.1  transforming acidic coiled-coil-containing protein 2 isoform X25

    Conserved Domains (2) summary
    pfam05010
    Location:9511151
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:331718
    DUF4045; Domain of unknown function (DUF4045)
  23. XM_011539130.1XP_011537432.1  transforming acidic coiled-coil-containing protein 2 isoform X26

    Conserved Domains (3) summary
    pfam05010
    Location:9081108
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:10271107
    FadA; Adhesion protein FadA
    cl23765
    Location:9271029
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  24. XM_024447758.1XP_024303526.1  transforming acidic coiled-coil-containing protein 2 isoform X2

    Conserved Domains (3) summary
    pfam05010
    Location:28043004
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21842571
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:23487
    Atrophin-1; Atrophin-1 family
  25. XM_024447759.1XP_024303527.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    Conserved Domains (3) summary
    pfam05010
    Location:27852985
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21652552
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:15468
    Atrophin-1; Atrophin-1 family
  26. XM_017015490.1XP_016870979.1  transforming acidic coiled-coil-containing protein 2 isoform X23

  27. XM_024447757.1XP_024303525.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    Conserved Domains (3) summary
    pfam05010
    Location:28053005
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:21852572
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24488
    Atrophin-1; Atrophin-1 family
  28. XM_024447767.1XP_024303535.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    Conserved Domains (1) summary
    pfam05010
    Location:489689
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  29. XM_024447768.1XP_024303536.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    Conserved Domains (1) summary
    pfam05010
    Location:489689
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  30. XM_017015499.1XP_016870988.1  transforming acidic coiled-coil-containing protein 2 isoform X35

  31. XM_011539134.2XP_011537436.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    See identical proteins and their annotated locations for XP_011537436.1

    UniProtKB/TrEMBL
    Q4VXL4
    Conserved Domains (1) summary
    pfam05010
    Location:369569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  32. XM_024447766.1XP_024303534.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    Conserved Domains (1) summary
    pfam05010
    Location:489689
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  33. XM_011539133.1XP_011537435.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    See identical proteins and their annotated locations for XP_011537435.1

    UniProtKB/TrEMBL
    Q4VXL4
    Related
    ENSP00000357996.1, ENST00000369000.5
    Conserved Domains (1) summary
    pfam05010
    Location:369569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  34. XM_024447765.1XP_024303533.1  transforming acidic coiled-coil-containing protein 2 isoform X28

    Conserved Domains (2) summary
    pfam05010
    Location:8631063
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:243630
    DUF4045; Domain of unknown function (DUF4045)
  35. XM_011539132.2XP_011537434.1  transforming acidic coiled-coil-containing protein 2 isoform X30

    UniProtKB/TrEMBL
    Q4VXL8
    Related
    ENSP00000357995.1, ENST00000368999.5
    Conserved Domains (3) summary
    pfam05010
    Location:8321032
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:9511031
    FadA; Adhesion protein FadA
    cl23765
    Location:851953
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  36. XM_017015495.2XP_016870984.1  transforming acidic coiled-coil-containing protein 2 isoform X33

  37. XM_017015493.2XP_016870982.1  transforming acidic coiled-coil-containing protein 2 isoform X31

  38. XM_017015491.1XP_016870980.1  transforming acidic coiled-coil-containing protein 2 isoform X27

  39. XM_017015492.1XP_016870981.1  transforming acidic coiled-coil-containing protein 2 isoform X29

  40. XM_017015494.1XP_016870983.1  transforming acidic coiled-coil-containing protein 2 isoform X32

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