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Scrib scribbled planar cell polarity [ Mus musculus (house mouse) ]

Gene ID: 105782, updated on 11-Apr-2024

Summary

Official Symbol
Scribprovided by MGI
Official Full Name
scribbled planar cell polarityprovided by MGI
Primary source
MGI:MGI:2145950
See related
Ensembl:ENSMUSG00000022568 AllianceGenome:MGI:2145950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crc; CRIB; Scrb1; SCRIB1; vartul; mKIAA0147
Summary
Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; hair follicle; and nervous system. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 45.6), thymus adult (RPKM 36.9) and 28 other tissues See more
Orthologs
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Genomic context

See Scrib in Genome Data Viewer
Location:
15 D3; 15 35.29 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75919011..75941633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76047162..76069784, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 15 Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene microRNA 6952 Neighboring gene poly-U binding splicing factor 60 Neighboring gene STARR-seq mESC enhancer starr_39038 Neighboring gene predicted gene, 48952 Neighboring gene nuclear receptor binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0147

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within auditory receptor cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in camera-type eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cochlear nucleus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial cell morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in establishment of T cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of apical/basal cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment or maintenance of epithelial cell apical/basal polarity TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in polarized epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to adherens junction ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Scrib-APC-beta-catenin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in apical plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein scribble homolog
Names
PDZ-domain protein scribble
circletail
scribble homolog 1
scribbled homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310542.1NP_001297471.1  protein scribble homolog isoform 2

    See identical proteins and their annotated locations for NP_001297471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (2) is shorter, missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK122211, BC062888
    Consensus CDS
    CCDS79382.1
    UniProtKB/Swiss-Prot
    Q80U72
    Related
    ENSMUSP00000105572.3, ENSMUST00000109946.9
    Conserved Domains (7) summary
    smart00228
    Location:711799
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:12232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:9881076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:289329
    LRR_4; Leucine Rich repeats (2 copies)
    pfam16182
    Location:15371631
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  2. NM_001310543.1NP_001297472.1  protein scribble homolog isoform 3

    See identical proteins and their annotated locations for NP_001297472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame coding exons in the 3' region compared to variant 1. The resulting isoform (3) is shorter, missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AK122211, BC062888
    Consensus CDS
    CCDS79381.1
    UniProtKB/Swiss-Prot
    Q6P5H7, Q7TPH8, Q80U72, Q80VB1, Q8CI48, Q8VII1, Q922S3
    Related
    ENSMUSP00000068056.6, ENSMUST00000063747.12
    Conserved Domains (4) summary
    smart00228
    Location:711799
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:9881076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_134089.2NP_598850.1  protein scribble homolog isoform 1

    See identical proteins and their annotated locations for NP_598850.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF441233, AK122211, BC062888
    Consensus CDS
    CCDS27560.1
    UniProtKB/Swiss-Prot
    Q80U72
    Related
    ENSMUSP00000002603.6, ENSMUST00000002603.12
    Conserved Domains (7) summary
    smart00228
    Location:711799
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:12232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:9881076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:289329
    LRR_4; Leucine Rich repeats (2 copies)
    pfam16182
    Location:15651659
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75919011..75941633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248260.1XP_030104120.1  protein scribble homolog isoform X6

    Conserved Domains (4) summary
    smart00228
    Location:160248
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK14971
    Location:722854
    PRK14971; DNA polymerase III subunit gamma/tau
    cd00992
    Location:437525
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16182
    Location:10171108
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  2. XM_006520242.3XP_006520305.1  protein scribble homolog isoform X5

    Conserved Domains (6) summary
    smart00228
    Location:484572
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39164
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    PRK14971
    Location:10461178
    PRK14971; DNA polymerase III subunit gamma/tau
    cd00992
    Location:761849
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:4163
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16182
    Location:13411432
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  3. XM_006520238.4XP_006520301.1  protein scribble homolog isoform X1

    Conserved Domains (6) summary
    smart00228
    Location:710798
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:9871075
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
    pfam15449
    Location:12171361
    Retinal; Retinal protein
    pfam16182
    Location:15671658
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  4. XM_017316355.3XP_017171844.1  protein scribble homolog isoform X4

    UniProtKB/Swiss-Prot
    Q80U72
    Conserved Domains (5) summary
    smart00228
    Location:693778
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    PRK14971
    Location:12521384
    PRK14971; DNA polymerase III subunit gamma/tau
    cd00992
    Location:9671055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_006520239.5XP_006520302.1  protein scribble homolog isoform X2

    Conserved Domains (6) summary
    smart00228
    Location:693778
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    PRK14971
    Location:12521384
    PRK14971; DNA polymerase III subunit gamma/tau
    cd00992
    Location:9671055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16182
    Location:15471638
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  6. XM_017316354.3XP_017171843.1  protein scribble homolog isoform X3

    Conserved Domains (5) summary
    smart00228
    Location:711799
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG4886
    Location:39405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00992
    Location:9881076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:1437
    LRR_RI; leucine-rich repeat [structural motif]
    pfam15449
    Location:12181362
    Retinal; Retinal protein

RNA

  1. XR_004938779.1 RNA Sequence

  2. XR_004938778.1 RNA Sequence

  3. XR_875207.4 RNA Sequence

  4. XR_003951338.2 RNA Sequence

  5. XR_004938777.1 RNA Sequence

  6. XR_875208.4 RNA Sequence

  7. XR_003951339.2 RNA Sequence

  8. XR_004938780.1 RNA Sequence