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CCT7 chaperonin containing TCP1 subunit 7 [ Homo sapiens (human) ]

Gene ID: 10574, updated on 4-Nov-2018

Summary

Official Symbol
CCT7provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 7provided by HGNC
Primary source
HGNC:HGNC:1622
See related
Ensembl:ENSG00000135624 MIM:605140; Vega:OTTHUMG00000152765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCTH; CCTETA; NIP7-1; TCP1ETA
Summary
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues See more
Orthologs

Genomic context

See CCT7 in Genome Data Viewer
Location:
2p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (73233425..73253022)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73461364..73480150)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SMYD family member 5 Neighboring gene protease associated domain containing 1 Neighboring gene F-box protein 41 Neighboring gene early growth response 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCT7 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with CCT7 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110985

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit eta
Names
CCT-eta
HIV-1 Nef interacting protein
TCP-1-eta
chaperonin containing t-complex polypeptide 1, eta subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047121.1 RefSeqGene

    Range
    5812..24598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009570.2NP_001009570.1  T-complex protein 1 subunit eta isoform b

    See identical proteins and their annotated locations for NP_001009570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    AK098825, AK293597, CX781741, DC362157, DC395264
    Consensus CDS
    CCDS42696.1
    UniProtKB/Swiss-Prot
    Q99832
    Related
    ENSP00000381456.2, OTTHUMP00000213063, ENST00000398422.2, OTTHUMT00000327751
    Conserved Domains (1) summary
    cl02777
    Location:1321
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  2. NM_001166284.1NP_001159756.1  T-complex protein 1 subunit eta isoform c

    See identical proteins and their annotated locations for NP_001159756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (c), compared to isoform a.
    Source sequence(s)
    AK098825, AK298153, CX781741, DC362157, DC395264
    Consensus CDS
    CCDS54366.1
    UniProtKB/Swiss-Prot
    Q99832
    Related
    ENSP00000442058.1, ENST00000540468.5
    Conserved Domains (1) summary
    cd03340
    Location:3438
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
  3. NM_001166285.1NP_001159757.1  T-complex protein 1 subunit eta isoform d

    See identical proteins and their annotated locations for NP_001159757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon in its 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK098825, AK297846, CX781741, DC362157, DC395264
    Consensus CDS
    CCDS54367.1
    UniProtKB/Swiss-Prot
    Q99832
    Related
    ENSP00000437824.1, ENST00000539919.5
    Conserved Domains (1) summary
    cd03340
    Location:1481
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
  4. NM_006429.3NP_006420.1  T-complex protein 1 subunit eta isoform a

    See identical proteins and their annotated locations for NP_006420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK098825, BC019296, CX781741, DC362157, DC395264
    Consensus CDS
    CCDS46336.1
    UniProtKB/Swiss-Prot
    Q99832
    Related
    ENSP00000258091.5, OTTHUMP00000202321, ENST00000258091.9, OTTHUMT00000327714
    Conserved Domains (1) summary
    cd03340
    Location:5525
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...

RNA

  1. NR_029402.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098825, AK293175, CX781741, DC362157, DC395264
  2. NR_029403.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098825, AK302078, CX781741, DC362157, DC395264

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    73233425..73253022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532478.3XP_011530780.1  T-complex protein 1 subunit eta isoform X1

    See identical proteins and their annotated locations for XP_011530780.1

    UniProtKB/Swiss-Prot
    Q99832
    Conserved Domains (1) summary
    cd03340
    Location:1481
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
  2. XM_011532479.2XP_011530781.1  T-complex protein 1 subunit eta isoform X1

    See identical proteins and their annotated locations for XP_011530781.1

    UniProtKB/Swiss-Prot
    Q99832
    Conserved Domains (1) summary
    cd03340
    Location:1481
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
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