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CCT7 chaperonin containing TCP1 subunit 7 [ Homo sapiens (human) ]

Gene ID: 10574, updated on 3-Dec-2024

Summary

Official Symbol
CCT7provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 7provided by HGNC
Primary source
HGNC:HGNC:1622
See related
Ensembl:ENSG00000135624 MIM:605140; AllianceGenome:HGNC:1622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCTH; CCTETA; NIP7-1; TCP1ETA
Summary
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues See more
Orthologs
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Genomic context

See CCT7 in Genome Data Viewer
Location:
2p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73234308..73253005)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73246421..73265996)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73461436..73480133)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2018 Neighboring gene SMYD family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11637 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73460911-73461442 Neighboring gene protease associated domain containing 1 Neighboring gene F-box protein 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:73496386-73497329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11641 Neighboring gene uncharacterized LOC124907840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11643

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCT7 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with CCT7 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC110985

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit eta
Names
CCT-eta
HIV-1 Nef interacting protein
TCP-1-eta
chaperonin containing T-complex polypeptide 1 subunit 7
chaperonin containing t-complex polypeptide 1, eta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047121.1 RefSeqGene

    Range
    5884..24581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009570.3NP_001009570.1  T-complex protein 1 subunit eta isoform b

    See identical proteins and their annotated locations for NP_001009570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    AK098825, AK293597, CX781741, DC395264
    Consensus CDS
    CCDS42696.1
    UniProtKB/Swiss-Prot
    Q99832
    Related
    ENSP00000381456.2, ENST00000398422.2
    Conserved Domains (1) summary
    cl02777
    Location:1321
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  2. NM_001166284.2NP_001159756.1  T-complex protein 1 subunit eta isoform c

    See identical proteins and their annotated locations for NP_001159756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (c), compared to isoform a.
    Source sequence(s)
    AK098825, AK298153, CX781741, DC395264
    Consensus CDS
    CCDS54366.1
    UniProtKB/TrEMBL
    B7Z7I4
    Related
    ENSP00000442058.1, ENST00000540468.5
    Conserved Domains (1) summary
    cd03340
    Location:3438
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
  3. NM_001166285.2NP_001159757.1  T-complex protein 1 subunit eta isoform d

    See identical proteins and their annotated locations for NP_001159757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate exon in its 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK098825, AK297846, CX781741
    Consensus CDS
    CCDS54367.1
    UniProtKB/TrEMBL
    Q53HV2, Q6IBT3
    Related
    ENSP00000437824.1, ENST00000539919.5
    Conserved Domains (1) summary
    cd03340
    Location:1481
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
  4. NM_006429.4NP_006420.1  T-complex protein 1 subunit eta isoform a

    See identical proteins and their annotated locations for NP_006420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK098825, BC019296, CX781741, DC395264
    Consensus CDS
    CCDS46336.1
    UniProtKB/Swiss-Prot
    A8K7E6, A8MWI8, B7WNW9, B7Z4T9, B7Z4Z7, O14871, Q6FI26, Q99832
    UniProtKB/TrEMBL
    Q53HV2
    Related
    ENSP00000258091.5, ENST00000258091.10
    Conserved Domains (1) summary
    cd03340
    Location:5525
    TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...

RNA

  1. NR_029402.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098825, AK293175, CX781741, DC395264
  2. NR_029403.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098825, AK302078, CX781741, DC395264

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    73234308..73253005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    73246421..73265996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340196.1XP_054196171.1  T-complex protein 1 subunit eta isoform X1

    UniProtKB/TrEMBL
    Q53HV2, Q6IBT3