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Slc38a1 solute carrier family 38, member 1 [ Mus musculus (house mouse) ]

Gene ID: 105727, updated on 13-Jan-2023

Summary

Official Symbol
Slc38a1provided by MGI
Official Full Name
solute carrier family 38, member 1provided by MGI
Primary source
MGI:MGI:2145895
See related
Ensembl:ENSMUSG00000023169 AllianceGenome:MGI:2145895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAT2; SNAT1; Gm32457
Summary
Enables L-glutamine transmembrane transporter activity. Acts upstream of or within glutamine transport. Located in axon and basolateral plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 28.9), placenta adult (RPKM 22.1) and 23 other tissues See more
Orthologs
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Genomic context

See Slc38a1 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96469299..96541396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96571418..96643438, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41392 Neighboring gene predicted gene, 32406 Neighboring gene predicted gene, 46503 Neighboring gene predicted gene, 22045

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alanine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid import ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of L-glutamine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium-coupled neutral amino acid symporter 1; sodium-coupled neutral amino acid transporter 1
Names
MNat2
N-system amino acid transporter 2
amino acid transporter A1
system A amino acid transporter 1
system N amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166456.1NP_001159928.1  sodium-coupled neutral amino acid symporter 1

    See identical proteins and their annotated locations for NP_001159928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC109201, AC123606, AK035098, AK082683
    Consensus CDS
    CCDS27777.1
    UniProtKB/Swiss-Prot
    Q8K2P7, Q99PR1
    Related
    ENSMUSP00000085801.6, ENSMUST00000088454.13
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001166458.1NP_001159930.1  sodium-coupled neutral amino acid symporter 1

    See identical proteins and their annotated locations for NP_001159930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC123606, AK081724
    Consensus CDS
    CCDS27777.1
    UniProtKB/Swiss-Prot
    Q8K2P7, Q99PR1
    Related
    ENSMUSP00000085799.5, ENSMUST00000088452.11
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_134086.4NP_598847.2  sodium-coupled neutral amino acid symporter 1

    See identical proteins and their annotated locations for NP_598847.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC123606, AK034130, AK165188
    Consensus CDS
    CCDS27777.1
    UniProtKB/Swiss-Prot
    Q8K2P7, Q99PR1
    Related
    ENSMUSP00000097833.3, ENSMUST00000100262.4
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    96469299..96541396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159052.1XP_036014945.1  sodium-coupled neutral amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99PR1
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_030248259.2XP_030104119.1  sodium-coupled neutral amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99PR1
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_030248257.2XP_030104117.1  sodium-coupled neutral amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99PR1
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_030248258.2XP_030104118.1  sodium-coupled neutral amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99PR1
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_006520235.5XP_006520298.1  sodium-coupled neutral amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006520298.1

    UniProtKB/Swiss-Prot
    Q8K2P7, Q99PR1
    Conserved Domains (1) summary
    cl00456
    Location:69472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_004938775.1 RNA Sequence

  2. XR_004938776.1 RNA Sequence