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SIVA1 SIVA1 apoptosis inducing factor [ Homo sapiens (human) ]

Gene ID: 10572, updated on 1-Aug-2020

Summary

Official Symbol
SIVA1provided by HGNC
Official Full Name
SIVA1 apoptosis inducing factorprovided by HGNC
Primary source
HGNC:HGNC:17712
See related
Ensembl:ENSG00000184990 MIM:605567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIVA; CD27BP; Siva-1; Siva-2
Summary
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues See more
Orthologs

Genomic context

See SIVA1 in Genome Data Viewer
Location:
14q32.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (104752420..104759659)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105219470..105225996)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene inverted formin 2 Neighboring gene skeletal muscle cis-regulatory module in INF2 and ADSSL1 intergenic region Neighboring gene adenylosuccinate synthase 1 Neighboring gene uncharacterized LOC107984670 Neighboring gene uncharacterized LOC107987209 Neighboring gene uncharacterized LOC102723342 Neighboring gene AKT serine/threonine kinase 1 Neighboring gene zinc finger and BTB domain containing 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SIVA1, apoptosis-inducing factor (SIVA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Envelope transmembrane glycoprotein gp41 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CD27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CD27 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
virus receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
apoptosis regulatory protein Siva
Names
CD27-binding (Siva) protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029449.1 RefSeqGene

    Range
    5015..11522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006427.4NP_006418.2  apoptosis regulatory protein Siva isoform 1

    See identical proteins and their annotated locations for NP_006418.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant and longer transcript. It encodes isoform 1 and includes the apoptotic properties of Siva.
    Source sequence(s)
    BC034562, BU195069, CK001877
    Consensus CDS
    CCDS9992.1
    UniProtKB/Swiss-Prot
    O15304
    Related
    ENSP00000329213.6, ENST00000329967.11
    Conserved Domains (1) summary
    pfam05458
    Location:1175
    Siva; Cd27 binding protein (Siva)
  2. NM_021709.3NP_068355.1  apoptosis regulatory protein Siva isoform 2

    See identical proteins and their annotated locations for NP_068355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC034562, BU195069
    Consensus CDS
    CCDS9993.1
    UniProtKB/Swiss-Prot
    O15304
    Related
    ENSP00000329447.6, ENST00000347067.9
    Conserved Domains (1) summary
    pfam05458
    Location:1110
    Siva; Cd27 binding protein (Siva)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    104752420..104759659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536360.2XP_011534662.1  apoptosis regulatory protein Siva isoform X1

    See identical proteins and their annotated locations for XP_011534662.1

    Conserved Domains (1) summary
    pfam05458
    Location:1157
    Siva; Cd27 binding protein (Siva)
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