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SLU7 SLU7 homolog, splicing factor [ Homo sapiens (human) ]

Gene ID: 10569, updated on 23-Nov-2021

Summary

Official Symbol
SLU7provided by HGNC
Official Full Name
SLU7 homolog, splicing factorprovided by HGNC
Primary source
HGNC:HGNC:16939
See related
Ensembl:ENSG00000164609 MIM:605974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9G8; hSlu7
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues See more
Orthologs
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Genomic context

See SLU7 in Genome Data Viewer
Location:
5q33.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160401641..160419081, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159828648..159846088, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 2 Neighboring gene zinc finger BED-type containing 8 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SLU7 splicing factor homolog (SLU7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pre-mRNA 3'-splice site binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables second spliceosomal transesterification activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor SLU7
Names
SLU7 splicing factor homolog
splicing factor
step II splicing factor SLU7
zinc knuckle motif containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364517.2NP_001351446.1  pre-mRNA-splicing factor SLU7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:176449
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  2. NM_001364518.2NP_001351447.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  3. NM_001364520.2NP_001351449.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  4. NM_001364521.2NP_001351450.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  5. NM_001364522.2NP_001351451.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:171444
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  6. NM_001364523.2NP_001351452.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:171444
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  7. NM_006425.5NP_006416.3  pre-mRNA-splicing factor SLU7 isoform b

    See identical proteins and their annotated locations for NP_006416.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
    Source sequence(s)
    AC091842, BC010634, BE221264, CA976106, DA232975, DA409854
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    O95391
    Related
    ENSP00000297151.4, ENST00000297151.9
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160401641..160419081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454327.1XP_024310095.1  pre-mRNA-splicing factor SLU7 isoform X2

    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
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