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SLU7 SLU7 homolog, splicing factor [ Homo sapiens (human) ]

Gene ID: 10569, updated on 6-Oct-2019

Summary

Official Symbol
SLU7provided by HGNC
Official Full Name
SLU7 homolog, splicing factorprovided by HGNC
Primary source
HGNC:HGNC:16939
See related
Ensembl:ENSG00000164609 MIM:605974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9G8; hSlu7
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues See more
Orthologs

Genomic context

See SLU7 in Genome Data Viewer
Location:
5q33.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160401641..160419081, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159828648..159846168, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 2 Neighboring gene zinc finger BED-type containing 8 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SLU7 splicing factor homolog (SLU7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
    Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription, organism-specific biosystem
    RNA Polymerase II Transcription
  • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
    mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pre-mRNA 3'-splice site binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to second spliceosomal transesterification activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
second spliceosomal transesterification activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing, via transesterification reactions IDA
Inferred from Direct Assay
more info
PubMed 
alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA 3'-splice site recognition IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor SLU7
Names
SLU7 splicing factor homolog
splicing factor
step II splicing factor SLU7
zinc knuckle motif containing

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364517.2NP_001351446.1  pre-mRNA-splicing factor SLU7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:176449
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  2. NM_001364518.2NP_001351447.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  3. NM_001364520.2NP_001351449.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  4. NM_001364521.2NP_001351450.1  pre-mRNA-splicing factor SLU7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  5. NM_001364522.2NP_001351451.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:171444
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  6. NM_001364523.2NP_001351452.1  pre-mRNA-splicing factor SLU7 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AC091842
    Conserved Domains (1) summary
    pfam11708
    Location:171444
    Slu7; Pre-mRNA splicing Prp18-interacting factor
  7. NM_006425.5NP_006416.3  pre-mRNA-splicing factor SLU7 isoform b

    See identical proteins and their annotated locations for NP_006416.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
    Source sequence(s)
    AC091842, BC010634, BE221264, CA976106, DA232975, DA409854
    Consensus CDS
    CCDS4352.1
    UniProtKB/Swiss-Prot
    O95391
    Related
    ENSP00000297151.4, ENST00000297151.9
    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160401641..160419081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454327.1XP_024310095.1  pre-mRNA-splicing factor SLU7 isoform X2

    Conserved Domains (1) summary
    pfam11708
    Location:161434
    Slu7; Pre-mRNA splicing Prp18-interacting factor
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