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AKAP3 A-kinase anchoring protein 3 [ Homo sapiens (human) ]

Gene ID: 10566, updated on 17-Jun-2019

Summary

Official Symbol
AKAP3provided by HGNC
Official Full Name
A-kinase anchoring protein 3provided by HGNC
Primary source
HGNC:HGNC:373
See related
Ensembl:ENSG00000111254 MIM:604689
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT82; SOB1; FSP95; PRKA3; HEL159; AKAP110; AKAP 110
Summary
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Expression
Restricted expression toward testis (RPKM 61.9) See more
Orthologs

Genomic context

See AKAP3 in Genome Data Viewer
Location:
12p13.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (4615508..4649051, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4723837..4758213, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10040 Neighboring gene coiled-coil domain containing 181 pseudogene Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene RAB5A, member RAS oncogene family pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene GALNT8 antisense upstream 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction TAS
Traceable Author Statement
more info
PubMed 
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single fertilization TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
sperm fibrous sheath IEA
Inferred from Electronic Annotation
more info
 
sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 3
Names
A kinase (PRKA) anchor protein 3
A-kinase anchor protein, 110kDa
Fibrous Sheath Protein of 95 kDa
cancer/testis antigen 82
epididymis luminal protein 159
epididymis secretory sperm binding protein
fibrousheathin I
fibrousheathin-1
protein kinase A binding protein AKAP 110
protein kinase A-anchoring protein 3
sperm oocyte-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278309.2NP_001265238.2  A-kinase anchor protein 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005832
    Consensus CDS
    CCDS8531.1
    Related
    ENSP00000228850.1, ENST00000228850.6
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
  2. NM_006422.3NP_006413.3  A-kinase anchor protein 3

    See identical proteins and their annotated locations for NP_006413.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF087003, AF093408, AI004486, AK292451
    Consensus CDS
    CCDS8531.1
    UniProtKB/Swiss-Prot
    O75969
    Related
    ENSP00000440994.1, ENST00000545990.6
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    4615508..4649051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520910.2XP_011519212.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011519212.1

    UniProtKB/Swiss-Prot
    O75969
    UniProtKB/TrEMBL
    V9HWD4
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
  2. XM_024448797.1XP_024304565.1  A-kinase anchor protein 3 isoform X1

    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
  3. XM_011520908.1XP_011519210.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011519210.1

    UniProtKB/Swiss-Prot
    O75969
    UniProtKB/TrEMBL
    V9HWD4
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
  4. XM_011520909.2XP_011519211.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011519211.1

    UniProtKB/Swiss-Prot
    O75969
    UniProtKB/TrEMBL
    V9HWD4
    Conserved Domains (1) summary
    smart00807
    Location:5853
    AKAP_110; A-kinase anchor protein 110 kDa
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