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OLFM4 olfactomedin 4 [ Homo sapiens (human) ]

Gene ID: 10562, updated on 3-Dec-2023

Summary

Official Symbol
OLFM4provided by HGNC
Official Full Name
olfactomedin 4provided by HGNC
Primary source
HGNC:HGNC:17190
See related
Ensembl:ENSG00000102837 MIM:614061; AllianceGenome:HGNC:17190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1
Summary
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Expression
Biased expression in small intestine (RPKM 721.2), duodenum (RPKM 639.8) and 4 other tissues See more
Orthologs
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Genomic context

See OLFM4 in Genome Data Viewer
Location:
13q14.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (53028813..53052057)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (52244407..52267681)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53602948..53626192)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53412585-53413086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53413087-53413586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53420960-53421848 Neighboring gene peptidylprolyl isomerase A pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53421849-53422738 Neighboring gene Sharpr-MPRA regulatory region 8019 Neighboring gene Sharpr-MPRA regulatory region 8029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7796 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:53453690-53454319 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:53454320-53454948 Neighboring gene protocadherin 8 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:53480206-53480776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53499618-53500118 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:53530858-53531358 Neighboring gene long intergenic non-protein coding RNA 1065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53776063-53776780 Neighboring gene protocadherin 8 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association meta-analysis identifies new childhood obesity loci.
EBI GWAS Catalog
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
NOT located_in azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactomedin-4
Names
G-CSF-stimulated clone 1 protein
antiapoptotic protein GW112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006418.5NP_006409.3  olfactomedin-4 precursor

    See identical proteins and their annotated locations for NP_006409.3

    Status: REVIEWED

    Source sequence(s)
    AI560739, AY358567, DA928098
    Consensus CDS
    CCDS9440.1
    UniProtKB/Swiss-Prot
    O95362, Q5VWG0, Q6UX06, Q86T22
    Related
    ENSP00000219022.2, ENST00000219022.3
    Conserved Domains (2) summary
    pfam02191
    Location:251503
    OLF; Olfactomedin-like domain
    cl25732
    Location:98233
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    53028813..53052057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    52244407..52267681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)