OLFM4 olfactomedin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OLFM4provided by HGNC
Official Full Name: olfactomedin 4provided by HGNC
Primary source: HGNC:HGNC:17190
See related: Ensembl:ENSG00000102837 MIM:614061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1
Summary: This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Expression: Biased expression in small intestine (RPKM 721.2), duodenum (RPKM 639.8) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	13	NC_000013.11 (53028813..53052057)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (53602948..53626192)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
Title: A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer.
Title: Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer.
Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC.
Title: Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC.
Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.
Title: Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.
Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.
Title: Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.
Prognostic Significance and Functional Relevance of Olfactomedin 4 in Early-Stage Hepatocellular Carcinoma.
Title: Prognostic Significance and Functional Relevance of Olfactomedin 4 in Early-Stage Hepatocellular Carcinoma.
circulating OLFM4 could be an interesting biomarker of early breast cancer.
Title: OLFM4 Expression in Ductal Carcinoma In Situ and in Invasive Breast Cancer Cohorts by a SWATH-Based Proteomic Approach.
high expression of OLFM4 was involved in chemoresistance and was an independent prognostic factor in pancreatic cancer
Title: High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.
Results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway.
Title: OLFM4 Inhibits Epithelial-Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells.
Three of the eight CpG sites in the OLFM4 gene promoter region were hypermethylated in cancerous prostate cells and reduced methylation of eight CpG sites was associated with increased OLFM4 mRNA expression. Findings suggest that OLFM4 plays an important tumor-suppressor role in prostate cancer progression and might be useful as a novel candidate biomarker for prostate cancer.
Title: Olfactomedin 4 downregulation is associated with tumor initiation, growth and progression in human prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
A genome-wide association meta-analysis identifies new childhood obesity loci. GeneReviews: Not available
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. GeneReviews: Not available
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. GeneReviews: Not available
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A002P14 (e-PCR)
- UniSTS:18783

NoName (e-PCR)
- UniSTS:490414

RH66409 (e-PCR)
- UniSTS:82685

Homology

Homologs of the OLFM4 gene: The OLFM4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 273 organisms have orthologs with human gene OLFM4
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in azurophil granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
NOT located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule lumen	TAS Traceable Author Statement more info
located_in tertiary granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactomedin-4

Names: G-CSF-stimulated clone 1 protein; antiapoptotic protein GW112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.