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RPP30 ribonuclease P/MRP subunit p30 [ Homo sapiens (human) ]

Gene ID: 10556, updated on 23-Nov-2021

Summary

Official Symbol
RPP30provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p30provided by HGNC
Primary source
HGNC:HGNC:17688
See related
Ensembl:ENSG00000148688 MIM:606115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG15
Expression
Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

See RPP30 in Genome Data Viewer
Location:
10q23.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (90871974..90908556)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92631731..92668313)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2653 Neighboring gene 5-hydroxytryptamine receptor 7 Neighboring gene Sharpr-MPRA regulatory region 7939 Neighboring gene RNA, U6 small nuclear 740, pseudogene Neighboring gene ankyrin repeat domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
The genetic architecture of economic and political preferences.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p30
Names
RNase P subunit 2
RNaseP protein p30
ribonuclease P/MRP 30kDa subunit
NP_001098016.1
NP_006404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104546.2NP_001098016.1  ribonuclease P protein subunit p30 isoform a

    See identical proteins and their annotated locations for NP_001098016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK095810, AL590622, BC044601, BM978236, DB049454, U77665
    Consensus CDS
    CCDS44458.1
    UniProtKB/Swiss-Prot
    P78346
    Related
    ENSP00000389182.1, ENST00000413330.5
    Conserved Domains (2) summary
    pfam01876
    Location:21224
    RNase_P_p30; RNase P subunit p30
    pfam13900
    Location:270299
    GVQW; Putative domain of unknown function
  2. NM_006413.5NP_006404.1  ribonuclease P protein subunit p30 isoform b

    See identical proteins and their annotated locations for NP_006404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL590622, AL833628, DB049454, U77665
    Consensus CDS
    CCDS7411.1
    UniProtKB/Swiss-Prot
    P78346
    Related
    ENSP00000360768.3, ENST00000371703.8
    Conserved Domains (1) summary
    pfam01876
    Location:21224
    RNase_P_p30; RNase P subunit p30

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    90871974..90908556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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