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AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 10554, updated on 11-Jun-2021

Summary

Official Symbol
AGPAT1provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:324
See related
Ensembl:ENSG00000204310 MIM:603099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G15; LPAATA; 1-AGPAT1; LPAAT-alpha
Summary
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 25.5), brain (RPKM 21.6) and 25 other tissues See more
Orthologs
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Genomic context

See AGPAT1 in Genome Data Viewer
Location:
6p21.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (32168212..32178108, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32135989..32145885, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.1802 Neighboring gene uncharacterized LOC100507547 Neighboring gene proline rich transmembrane protein 1 Neighboring gene PPT2-EGFL8 readthrough (NMD candidate) Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene EGF like domain multiple 8 Neighboring gene microRNA 6721 Neighboring gene microRNA 6833 Neighboring gene ring finger protein 5 Neighboring gene advanced glycosylation end-product specific receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
GeneReviews: Not available
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4007, MGC5423

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Names
1-AGP acyltransferase 1
1-AGPAT 1
1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase)
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
epididymis secretory sperm binding protein
lysophosphatidic acid acyltransferase alpha
lysophospholipid acyltransferase
NP_001358366.1
NP_001358367.1
NP_001358368.1
NP_006402.1
NP_116130.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371437.1NP_001358366.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (2)
    Source sequence(s)
    AL662884
    Related
    ENST00000490711.5
    Conserved Domains (1) summary
    cd07989
    Location:73259
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
  2. NM_001371438.1NP_001358367.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and uses a downstream start codon compared to variant 3. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AL662884
    Related
    ENSP00000364245.2, ENST00000375104.6
    Conserved Domains (1) summary
    cd07989
    Location:69255
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
  3. NM_001371439.1NP_001358368.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, and uses a downstream start codon compared to variant 3. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AL662884
    Related
    ENSP00000378874.1, ENST00000395496.5
    Conserved Domains (1) summary
    cd07989
    Location:69255
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
  4. NM_006411.4NP_006402.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_006402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, and uses a downstream start codon compared to variant 3. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AI193422, BC004310, DA529681
    Consensus CDS
    CCDS4744.1
    UniProtKB/Swiss-Prot
    Q99943
    UniProtKB/TrEMBL
    A0A024RCV5
    Related
    ENSP00000364248.3, ENST00000375107.8
    Conserved Domains (1) summary
    cd07989
    Location:69255
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
  5. NM_032741.5NP_116130.2  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_116130.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses a downstream start codon compared to variant 3. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AI193422, BC002402, BM763275, DB118884
    Consensus CDS
    CCDS4744.1
    UniProtKB/Swiss-Prot
    Q99943
    UniProtKB/TrEMBL
    A0A024RCV5
    Related
    ENSP00000337463.6, ENST00000336984.6
    Conserved Domains (1) summary
    cd07989
    Location:69255
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    32168212..32178108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    3500814..3510710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3606564..3616460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    3473193..3483089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    3510233..3520129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    3391413..3401309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    3484419..3494315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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