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HTATIP2 HIV-1 Tat interactive protein 2 [ Homo sapiens (human) ]

Gene ID: 10553, updated on 1-Mar-2024

Summary

Official Symbol
HTATIP2provided by HGNC
Official Full Name
HIV-1 Tat interactive protein 2provided by HGNC
Primary source
HGNC:HGNC:16637
See related
Ensembl:ENSG00000109854 MIM:605628; AllianceGenome:HGNC:16637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CC3; TIP30; SDR44U1
Summary
Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 33.4), small intestine (RPKM 30.9) and 24 other tissues See more
Orthologs
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Genomic context

See HTATIP2 in Genome Data Viewer
Location:
11p15.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (20363714..20383782)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (20484405..20504464)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (20385260..20405328)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:20177816-20179015 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20182401-20182902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20182903-20183402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:20184527-20185028 Neighboring gene uncharacterized LOC105376583 Neighboring gene developing brain homeobox 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:20234917-20235147 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19843 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20364173-20364700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4525 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:20385467-20385609 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:20388793-20389992 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20406589-20407090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20409013-20409620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20409621-20410227 Neighboring gene protein arginine methyltransferase 3 Neighboring gene uncharacterized LOC124902808 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19926 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3204 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20566010-20566716 Neighboring gene uncharacterized LOC105376584 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_20020

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with HTATIP2 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat stimulates the phosphorylation of the RNA polymerase II C-terminal domain by TIP30 PubMed
tat TIP30 interacts with amino acids 1-48 of HIV-1 Tat, including the Tat activation domain, and enhances Tat activation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
oxidoreductase HTATIP2
Names
30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2
HIV-1 Tat interactive protein 2, 30kDa
Tat-interacting protein (30kD)
short chain dehydrogenase/reductase family 44U, member 1
NP_001091990.1
NP_001091991.1
NP_001091992.1
NP_001091993.1
NP_006401.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098520.2NP_001091990.1  oxidoreductase HTATIP2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC025972, AK222969, BC015358, BP382529
    Consensus CDS
    CCDS44553.1
    UniProtKB/Swiss-Prot
    Q9BUP3
    Related
    ENSP00000392985.2, ENST00000419348.6
    Conserved Domains (2) summary
    cd05250
    Location:53265
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    COG0702
    Location:55205
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
  2. NM_001098521.2NP_001091991.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001091991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC025972, AK222969, BC015358, DB450790
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000387876.2, ENST00000443524.6
    Conserved Domains (1) summary
    cd05250
    Location:19231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
  3. NM_001098522.2NP_001091992.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001091992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' end and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC025972, AI193677, AK222969, BC015358
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000394259.2, ENST00000451739.7
    Conserved Domains (1) summary
    cd05250
    Location:19231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
  4. NM_001098523.2NP_001091993.1  oxidoreductase HTATIP2 isoform c

    See identical proteins and their annotated locations for NP_001091993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and coding region, compared to variant 1. The resulting isoform (c, also known as TC3) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC025972, AF092095, AW963626
    Consensus CDS
    CCDS53613.1
    UniProtKB/Swiss-Prot
    Q9BUP3
    Related
    ENSP00000432107.1, ENST00000532081.1
    Conserved Domains (1) summary
    cl21454
    Location:19101
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_006410.5NP_006401.3  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_006401.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AK222969, BC015358, BF681178
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000397752.2, ENST00000421577.6
    Conserved Domains (1) summary
    cd05250
    Location:19231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    20363714..20383782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    20484405..20504464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)