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ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 [ Homo sapiens (human) ]

Gene ID: 10550, updated on 5-Sep-2021

Summary

Official Symbol
ARL6IP5provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 6 interacting protein 5provided by HGNC
Primary source
HGNC:HGNC:16937
See related
Ensembl:ENSG00000144746 MIM:605709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18
Summary
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 104.3), heart (RPKM 86.8) and 25 other tissues See more
Orthologs
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Genomic context

See ARL6IP5 in Genome Data Viewer
Location:
3p14.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (69084937..69106092)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (69134088..69155243)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TATA element modulatory factor 1 Neighboring gene microRNA 3136 Neighboring gene ubiquitin like modifier activating enzyme 3 Neighboring gene leiomodin 3 Neighboring gene FERM domain containing 4B Neighboring gene RNA binding motif protein 43 pseudogene 1 Neighboring gene H1.8 linker histone pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of L-glutamate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron death in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PRA1 family protein 3
Names
ADP-ribosylation factor GTPase 6 interacting protein 5
ADP-ribosylation factor-like 6 interacting protein 5
ADP-ribosylation factor-like protein 6-interacting protein 5
ADP-ribosylation-like factor 6 interacting protein 5
ARL-6-interacting protein 5
JM5
PRA1 domain family 3
aip-5
cytoskeleton-related vitamin A-responsive protein
dermal papilla derived protein 11
glutamate transporter EAAC1-interacting protein
glutamate transporter EEAC1-associated protein
prenylated Rab acceptor protein 2
protein JWa
putative MAPK activating protein PM27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006407.4NP_006398.1  PRA1 family protein 3

    See identical proteins and their annotated locations for NP_006398.1

    Status: REVIEWED

    Source sequence(s)
    AC092060, AF070523, AF125530, BG483337, BU149630
    Consensus CDS
    CCDS2912.1
    UniProtKB/Swiss-Prot
    O75915
    UniProtKB/TrEMBL
    A0A024R371
    Related
    ENSP00000273258.3, ENST00000273258.4
    Conserved Domains (1) summary
    pfam03208
    Location:3148
    PRA1; PRA1 family protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    69084937..69106092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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