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TM9SF1 transmembrane 9 superfamily member 1 [ Homo sapiens (human) ]

Gene ID: 10548, updated on 6-Jan-2019

Summary

Official Symbol
TM9SF1provided by HGNC
Official Full Name
transmembrane 9 superfamily member 1provided by HGNC
Primary source
HGNC:HGNC:11864
See related
Ensembl:ENSG00000100926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MP70; HMP70
Expression
Ubiquitous expression in thyroid (RPKM 24.3), prostate (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See TM9SF1 in Genome Data Viewer
Location:
14q12
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (24189143..24195736, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24658353..24666288, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4 Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TM9SF1; predicted interaction to be within the endoplasmic reticulum and involved in autophagy PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: IPO4

Potential readthrough

Included gene: CHMP4A

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane 9 superfamily member 1
Names
MP70 protein family member
multispanning membrane protein (70kD)
transmembrane protein 9 superfamily member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014842.2NP_001014842.1  transmembrane 9 superfamily member 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001014842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AW015727, BX161494, DB524698, HY174389
    Consensus CDS
    CCDS41934.1
    UniProtKB/Swiss-Prot
    O15321
    Related
    ENSP00000380063.4, ENST00000396854.8
    Conserved Domains (1) summary
    pfam02990
    Location:58475
    EMP70; Endomembrane protein 70
  2. NM_001289006.1NP_001275935.1  transmembrane 9 superfamily member 1 isoform c

    See identical proteins and their annotated locations for NP_001275935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK304642, AW452952, BX161390, HY174389
    Consensus CDS
    CCDS73623.1
    UniProtKB/Swiss-Prot
    O15321
    UniProtKB/TrEMBL
    B4E3A9, G3V1B9
    Related
    ENSP00000434387.1, ENST00000524835.5
    Conserved Domains (1) summary
    pfam02990
    Location:1475
    EMP70; Endomembrane protein 70
  3. NM_006405.7NP_006396.2  transmembrane 9 superfamily member 1 isoform a precursor

    See identical proteins and their annotated locations for NP_006396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AW452952, BX161390
    Consensus CDS
    CCDS9617.1
    UniProtKB/Swiss-Prot
    O15321
    Related
    ENSP00000261789.4, ENST00000261789.8
    Conserved Domains (1) summary
    pfam02990
    Location:59562
    EMP70; Endomembrane protein 70

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    24189143..24195736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p12 PATCHES

    Range
    490121..496714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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