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Mmrn2 multimerin 2 [ Mus musculus (house mouse) ]

Gene ID: 105450, updated on 12-May-2024

Summary

Official Symbol
Mmrn2provided by MGI
Official Full Name
multimerin 2provided by MGI
Primary source
MGI:MGI:2385618
See related
Ensembl:ENSMUSG00000041445 AllianceGenome:MGI:2385618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emilin3; ENDOGLYX1; EndoGlyx-1
Summary
Predicted to be an extracellular matrix structural constituent. Involved in cell migration involved in sprouting angiogenesis. Located in basement membrane. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 15.0), lung adult (RPKM 10.2) and 24 other tissues See more
Orthologs
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Genomic context

See Mmrn2 in Genome Data Viewer
Location:
14 B; 14 20.81 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34097461..34126244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34375504..34404287)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36378 Neighboring gene predicted gene, 41131 Neighboring gene STARR-seq mESC enhancer starr_36379 Neighboring gene synuclein, gamma Neighboring gene STARR-seq mESC enhancer starr_36380 Neighboring gene bone morphogenetic protein receptor, type 1A Neighboring gene RIKEN cDNA 9230112D13 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC41271

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multimerin-2
Names
elastin microfibril interfacer 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153127.3NP_694767.3  multimerin-2 precursor

    See identical proteins and their annotated locations for NP_694767.3

    Status: VALIDATED

    Source sequence(s)
    AC160930, AK077884, AK134285
    Consensus CDS
    CCDS36876.1
    UniProtKB/Swiss-Prot
    A6H6E2, Q8BJX4, Q8K1Z7
    Related
    ENSMUSP00000107539.2, ENSMUST00000111908.3
    Conserved Domains (2) summary
    pfam00386
    Location:821940
    C1q; C1q domain
    pfam07546
    Location:56126
    EMI; EMI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34097461..34126244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)