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ANP32B acidic nuclear phosphoprotein 32 family member B [ Homo sapiens (human) ]

Gene ID: 10541, updated on 9-Dec-2018

Summary

Official Symbol
ANP32Bprovided by HGNC
Official Full Name
acidic nuclear phosphoprotein 32 family member Bprovided by HGNC
Primary source
HGNC:HGNC:16677
See related
Ensembl:ENSG00000136938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APRIL; SSP29; PHAPI2
Expression
Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues See more
Orthologs

Genomic context

See ANP32B in Genome Data Viewer
Location:
9q22.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (97983207..98015943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100745479..100780860)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase O Neighboring gene hemogen Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev The interaction of Rev with ANP32B is decreased by the presence of RRE PubMed
rev HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
vasculature development IEA
Inferred from Electronic Annotation
more info
 
ventricular system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member B
Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
acidic protein rich in leucines
putative HLA-DR-associated protein I-2
silver-stainable protein SSP29

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006401.3NP_006392.1  acidic leucine-rich nuclear phosphoprotein 32 family member B

    See identical proteins and their annotated locations for NP_006392.1

    Status: VALIDATED

    Source sequence(s)
    AW296974, BC019658, BP395780
    Consensus CDS
    CCDS6732.1
    UniProtKB/Swiss-Prot
    Q92688
    Related
    ENSP00000345848.4, ENST00000339399.4
    Conserved Domains (2) summary
    sd00035
    Location:90113
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam12799
    Location:88130
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    97983207..98015943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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