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ANP32B acidic nuclear phosphoprotein 32 family member B [ Homo sapiens (human) ]

Gene ID: 10541, updated on 13-May-2022

Summary

Official Symbol
ANP32Bprovided by HGNC
Official Full Name
acidic nuclear phosphoprotein 32 family member Bprovided by HGNC
Primary source
HGNC:HGNC:16677
See related
Ensembl:ENSG00000136938 MIM:619823; AllianceGenome:HGNC:16677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APRIL; SSP29; PHAPI2
Summary
Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues See more
Orthologs
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Genomic context

See ANP32B in Genome Data Viewer
Location:
9q22.33
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97983341..98015943)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110155281..110187884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100745623..100778225)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4249 Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594 Neighboring gene uncharacterized LOC124902226 Neighboring gene uncharacterized LOC124902225 Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene uncharacterized LOC124902227 Neighboring gene tripartite motif containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev The interaction of Rev with ANP32B is decreased by the presence of RRE PubMed
rev HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member B
Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
acidic protein rich in leucines
putative HLA-DR-associated protein I-2
silver-stainable protein SSP29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006401.3NP_006392.1  acidic leucine-rich nuclear phosphoprotein 32 family member B

    See identical proteins and their annotated locations for NP_006392.1

    Status: VALIDATED

    Source sequence(s)
    AW296974, BC019658, BP395780
    Consensus CDS
    CCDS6732.1
    UniProtKB/Swiss-Prot
    Q92688
    Related
    ENSP00000345848.4, ENST00000339399.5
    Conserved Domains (2) summary
    sd00035
    Location:90113
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:71146
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    97983341..98015943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110155281..110187884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)