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GLRX3 glutaredoxin 3 [ Homo sapiens (human) ]

Gene ID: 10539, updated on 5-Apr-2020

Summary

Official Symbol
GLRX3provided by HGNC
Official Full Name
glutaredoxin 3provided by HGNC
Primary source
HGNC:HGNC:15987
See related
Ensembl:ENSG00000108010 MIM:612754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3
Summary
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See GLRX3 in Genome Data Viewer
Location:
10q26.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (130136375..130182877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (131934639..131978646)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 143 Neighboring gene uncharacterized LOC102724883 Neighboring gene uncharacterized LOC105378561 Neighboring gene CTAGE family member 7, pseudogene Neighboring gene long intergenic non-protein coding RNA 2646 Neighboring gene zinc finger protein 717 pseudogene Neighboring gene uncharacterized LOC105378562

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
[2Fe-2S] cluster assembly IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutaredoxin-3
Names
PKC-interacting cousin of thioredoxin
PKC-theta-interacting protein
PKCq-interacting protein
glutaredoxin 4
testicular tissue protein Li 75
thioredoxin-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029886.1 RefSeqGene

    Range
    5001..49008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199868.1NP_001186797.1  glutaredoxin-3 isoform 1

    See identical proteins and their annotated locations for NP_001186797.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF118652, AK022131, AL139123, BI256922
    Consensus CDS
    CCDS7661.1
    UniProtKB/Swiss-Prot
    O76003
    UniProtKB/TrEMBL
    A0A140VJK1
    Related
    ENSP00000357633.1, ENST00000368644.5
    Conserved Domains (2) summary
    cd02984
    Location:18113
    TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
    cd03028
    Location:137225
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
  2. NM_001321980.1NP_001308909.1  glutaredoxin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL139123
    Conserved Domains (1) summary
    cd03028
    Location:93181
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
  3. NM_006541.5NP_006532.2  glutaredoxin-3 isoform 1

    See identical proteins and their annotated locations for NP_006532.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA995117, AL139123, BC005289, BP347054
    Consensus CDS
    CCDS7661.1
    UniProtKB/Swiss-Prot
    O76003
    UniProtKB/TrEMBL
    A0A140VJK1
    Related
    ENSP00000330836.5, ENST00000331244.10
    Conserved Domains (2) summary
    cd02984
    Location:18113
    TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
    cd03028
    Location:137225
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    130136375..130182877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015474.1XP_016870963.1  glutaredoxin-3 isoform X1

    Conserved Domains (1) summary
    cd03028
    Location:93181
    GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
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