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BATF basic leucine zipper ATF-like transcription factor [ Homo sapiens (human) ]

Gene ID: 10538, updated on 17-Jun-2019

Summary

Official Symbol
BATFprovided by HGNC
Official Full Name
basic leucine zipper ATF-like transcription factorprovided by HGNC
Primary source
HGNC:HGNC:958
See related
Ensembl:ENSG00000156127 MIM:612476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFA2; B-ATF; BATF1; SFA-2
Summary
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues See more
Orthologs

Genomic context

See BATF in Genome Data Viewer
Location:
14q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75522469..75547004)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75988784..76013335)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928377 Neighboring gene Jun dimerization protein 2 Neighboring gene uncharacterized LOC105370572 Neighboring gene uncharacterized LOC107984652 Neighboring gene uncharacterized LOC107984653 Neighboring gene uncharacterized LOC102724153 Neighboring gene feline leukemia virus subgroup C cellular receptor family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphoid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
basic leucine zipper transcriptional factor ATF-like
Names
B-cell-activating transcription factor
SF-HT-activated gene 2 protein
activating transcription factor B
basic leucine zipper transcription factor, ATF-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006399.4NP_006390.1  basic leucine zipper transcriptional factor ATF-like

    See identical proteins and their annotated locations for NP_006390.1

    Status: REVIEWED

    Source sequence(s)
    AC007182, BC032294, BP235761, U15460
    Consensus CDS
    CCDS9843.1
    UniProtKB/Swiss-Prot
    Q16520
    Related
    ENSP00000286639.6, ENST00000286639.6
    Conserved Domains (1) summary
    cd14701
    Location:2683
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75522469..75547004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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