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KLF18 KLF transcription factor 18 [ Homo sapiens (human) ]

Gene ID: 105378952, updated on 25-Nov-2025
Official Symbol
KLF18provided by HGNC
Official Full Name
KLF transcription factor 18provided by HGNC
Primary source
HGNC:HGNC:51793
See related
Ensembl:ENSG00000283039 MIM:621009; AllianceGenome:HGNC:51793
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See KLF18 in Genome Data Viewer
Location:
1p34.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44137821..44141631, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44008117..44012630, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44603493..44607303, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 17 Neighboring gene KLF17 promoter region Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:44585039-44585806 Neighboring gene RNA, 7SL, cytoplasmic 479, pseudogene Neighboring gene small nuclear ribonucleoprotein Sm D1 pseudogene Neighboring gene zinc finger protein 146 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 936 Neighboring gene oocyte secreted protein 1 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A new family of predicted Krüppel-like factor genes and pseudogenes in placental mammals. Pei J, et al. PLoS One, 2013. PMID 24244731, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Kruppel-like factor 18
Names
KLF pseudogene
Kruppel like factor 18

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358438.1 → NP_001345367.1  Kruppel-like factor 18

    Status: INFERRED

    Source sequence(s)
    AL359839
    Consensus CDS
    CCDS85967.1
    UniProtKB/Swiss-Prot
    A0A0U1RQI7
    Related
    ENSP00000489024.1, ENST00000634670.1
    Conserved Domains (2) summary
    sd00017
    Location:969 → 988
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1010 → 1035
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    44137821..44141631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44008117..44012630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443665.1 → XP_047299621.1  Kruppel-like factor 18 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_042173.1: Suppressed sequence

    Description
    NG_042173.1: This RefSeq was removed because it is now thought that this locus produces a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0U1RQI7.1 GenPept UniProtKB/Swiss-Prot:A0A0U1RQI7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials