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HYOU1 hypoxia up-regulated 1 [ Homo sapiens (human) ]

Gene ID: 10525, updated on 8-Jul-2018
Official Symbol
HYOU1provided by HGNC
Official Full Name
hypoxia up-regulated 1provided by HGNC
Primary source
HGNC:HGNC:16931
See related
Ensembl:ENSG00000149428 MIM:601746; Vega:OTTHUMG00000166354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Grp170; HSP12A; ORP150; GRP-170; ORP-150
Summary
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in thyroid (RPKM 93.3), testis (RPKM 55.6) and 25 other tissues See more
Orthologs
See HYOU1 in Genome Data Viewer
Location:
11q23.3
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (119044185..119057246, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118914896..118927951, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 4 Neighboring gene solute carrier family 37 member 4 Neighboring gene VPS11, CORVET/HOPS core subunit Neighboring gene hydroxymethylbilane synthase

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with hypoxia up-regulated 1 (HYOU1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with HYOU1; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of hypoxia up-regulated 1 (HYOU1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Scavenging by Class F Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class F Receptors, organism-specific biosystemSCARF1 (SREC-I) and SCARF2 (SREC-II) are transmembrane proteins that contain multiple extracellular EGF-like domains (Ishii et al. 2002, reviewed in Areschoug and Gordon 2009). SCARF2 may be involved...
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ94899, FLJ97572, DKFZp686N08236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
membrane HDA PubMed 
smooth endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
hypoxia up-regulated protein 1
Names
150 kDa oxygen-regulated protein
170 kDa glucose-regulated protein
oxygen regulated protein (150kD)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130991.2NP_001124463.1  hypoxia up-regulated protein 1 precursor

    See identical proteins and their annotated locations for NP_001124463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AA580314, AK127324, AK299648, AK301514, BC072436, HY089857, U65785
    Consensus CDS
    CCDS8408.1
    UniProtKB/Swiss-Prot
    Q9Y4L1
    UniProtKB/TrEMBL
    B3KXH0, B7Z602, B7Z766, Q6IN67
    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35676
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_006389.4NP_006380.1  hypoxia up-regulated protein 1 precursor

    See identical proteins and their annotated locations for NP_006380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA580314, AK127324, AK301514, BC072436, DC364982, HY089857, U65785
    Consensus CDS
    CCDS8408.1
    UniProtKB/Swiss-Prot
    Q9Y4L1
    UniProtKB/TrEMBL
    B3KXH0, B7Z766, Q6IN67
    Related
    ENSP00000480150.1, OTTHUMP00000276905, ENST00000617285.4, OTTHUMT00000389353
    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35676
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    119044185..119057246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271392.4XP_005271449.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271449.1

    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35672
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_005271393.3XP_005271450.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271450.1

    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35672
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_017017095.1XP_016872584.1  hypoxia up-regulated protein 1 isoform X1

    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35672
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_017017097.1XP_016872586.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y4L1
    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35676
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. XM_017017096.1XP_016872585.1  hypoxia up-regulated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y4L1
    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35676
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. XM_005271394.3XP_005271451.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005271451.1

    Conserved Domains (3) summary
    PHA00666
    Location:601739
    PHA00666; putative protease
    pfam00012
    Location:35672
    HSP70; Hsp70 protein
    cl17037
    Location:36424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_001747729.1 RNA Sequence

  2. XR_002957117.1 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_009646203.1 Reference GRCh38.p12 PATCHES

    Range
    65784..78845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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