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ZNF211 zinc finger protein 211 [ Homo sapiens (human) ]

Gene ID: 10520, updated on 5-Nov-2017
Official Symbol
ZNF211provided by HGNC
Official Full Name
zinc finger protein 211provided by HGNC
Primary source
HGNC:HGNC:13003
See related
Ensembl:ENSG00000121417 MIM:601856; Vega:OTTHUMG00000168012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF-25; C2H2-25; CH2H2-25
Summary
This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Orthologs
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (57633167..57644046)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58144535..58155409)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 530 Neighboring gene zinc finger protein 134 Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 551

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 211
Names
zinc finger protein C2H2-25

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034028.1 RefSeqGene

    Range
    5001..15880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001265597.2NP_001252526.1  zinc finger protein 211 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AL559417, BQ678885, DA961612, DR002950
    Consensus CDS
    CCDS58686.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000299871.5, OTTHUMP00000237580, ENST00000299871.9, OTTHUMT00000397506
    Conserved Domains (6) summary
    smart00349
    Location:46106
    KRAB; krueppel associated box
    COG5048
    Location:244615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518540
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001265598.2NP_001252527.1  zinc finger protein 211 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC003682, AK294869, BQ678885, DA961612, DR002950
    Consensus CDS
    CCDS74468.1
    UniProtKB/Swiss-Prot
    Q13398
    UniProtKB/TrEMBL
    A0A0A0MTK1
    Related
    ENSP00000442601.2, ENST00000541801.5
    Conserved Domains (6) summary
    smart00349
    Location:3393
    KRAB; krueppel associated box
    COG5048
    Location:231602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:505527
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3372
    KRAB; KRAB box
    pfam13465
    Location:407432
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001265599.2NP_001252528.1  zinc finger protein 211 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK296942, BQ678885, DA961612
    Consensus CDS
    CCDS58687.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000254182.7, OTTHUMP00000237578, ENST00000254182.11, OTTHUMT00000397504
    Conserved Domains (4) summary
    COG5048
    Location:170541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:444466
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:346371
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001265600.2NP_001252529.1  zinc finger protein 211 isoform 6

    See identical proteins and their annotated locations for NP_001252529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK304666, BQ678885, DA961612
    Consensus CDS
    CCDS58688.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000375584.3, OTTHUMP00000237579, ENST00000391703.3, OTTHUMT00000397505
    Conserved Domains (4) summary
    COG5048
    Location:234489
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:392414
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:294319
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001322306.1NP_001309235.1  zinc finger protein 211

    Status: VALIDATED

    Source sequence(s)
    AC003682, BQ678885, DA961612
    Conserved Domains (4) summary
    COG5048
    Location:242613
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516538
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418443
    zf-H2C2_2; Zinc-finger double domain
  6. NM_006385.4NP_006376.2  zinc finger protein 211 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC003682, AK294869, BQ678885, DA745028, DA961612
    Consensus CDS
    CCDS12956.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000240731.4, OTTHUMP00000237582, ENST00000240731.4, OTTHUMT00000397509
    Conserved Domains (6) summary
    smart00349
    Location:4687
    KRAB; krueppel associated box
    COG5048
    Location:192563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:468488
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:466488
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain
  7. NM_198855.3NP_942152.1  zinc finger protein 211 isoform 2

    See identical proteins and their annotated locations for NP_942152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK304666, BC034351, BQ678885, DA961612
    Consensus CDS
    CCDS12957.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000339562.3, OTTHUMP00000237576, ENST00000347302.7, OTTHUMT00000397502
    Conserved Domains (6) summary
    smart00349
    Location:3374
    KRAB; krueppel associated box
    COG5048
    Location:179550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:455475
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:453475
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3372
    KRAB; KRAB box
    pfam13465
    Location:355380
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_049752.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, BC018138, BQ678885, DA961612
  2. NR_049753.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, BC110856, BQ678885, DA961612
  3. NR_049754.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, AK297047, BQ678885, DA961612

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    57633167..57644046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    58138480..58149319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290231.1: Suppressed sequence

    Description
    NM_001290231.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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