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CEBPD CCAAT enhancer binding protein delta [ Homo sapiens (human) ]

Gene ID: 1052, updated on 6-Sep-2022

Summary

Official Symbol
CEBPDprovided by HGNC
Official Full Name
CCAAT enhancer binding protein deltaprovided by HGNC
Primary source
HGNC:HGNC:1835
See related
Ensembl:ENSG00000221869 MIM:116898; AllianceGenome:HGNC:1835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CELF; CRP3; C/EBP-delta; NF-IL6-beta
Summary
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
Orthologs
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Genomic context

See CEBPD in Genome Data Viewer
Location:
8q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (47736913..47738164, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (48112630..48113881, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48649475..48650726, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scaffold protein involved in DNA repair Neighboring gene ubiquitin conjugating enzyme E2 N pseudogene Neighboring gene RNA, U6 small nuclear 665, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7649 Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene uncharacterized LOC105375818

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates C/EBPdelta expression in human mesenchymal stem cells PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of CCAAT/enhancer binding protein (C/EBP), delta (CEBPD) in primary human brain microvascular endothelial cells PubMed
Vpr vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of CXCL8 (IL8) in astrocytes PubMed
vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of IL6 in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IC
Inferred by Curator
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein delta
Names
CCAAT/enhancer binding protein (C/EBP), delta
c/EBP delta
nuclear factor NF-IL6-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005195.4NP_005186.2  CCAAT/enhancer-binding protein delta

    See identical proteins and their annotated locations for NP_005186.2

    Status: REVIEWED

    Source sequence(s)
    AC023991, BC105109, BQ773696, M83667
    Consensus CDS
    CCDS6142.1
    UniProtKB/Swiss-Prot
    P49716, Q2M2X9
    Related
    ENSP00000386165.3, ENST00000408965.4
    Conserved Domains (1) summary
    cd14714
    Location:188252
    bZIP_CEBPD; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein delta (CEBPD): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    47736913..47738164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    48112630..48113881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)