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FBXW10 F-box and WD repeat domain containing 10 [ Homo sapiens (human) ]

Gene ID: 10517, updated on 18-Aug-2020

Summary

Official Symbol
FBXW10provided by HGNC
Official Full Name
F-box and WD repeat domain containing 10provided by HGNC
Primary source
HGNC:HGNC:1211
See related
Ensembl:ENSG00000171931 MIM:611679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HREP; Fbw10; SM25H2; SM2SH2
Summary
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 6.8) and esophagus (RPKM 0.4) See more
Orthologs

Genomic context

See FBXW10 in Genome Data Viewer
Location:
17p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (18744024..18779349)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18647326..18682662)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286B (pseudogene) Neighboring gene forkhead box O3B Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 2 Neighboring gene tripartite motif containing 16 like Neighboring gene Sharpr-MPRA regulatory region 2370 Neighboring gene trans-golgi network vesicle protein 23 homolog B Neighboring gene coiled-coil domain-containing protein 144A-like Neighboring gene RNA, 7SL, cytoplasmic 627, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/WD repeat-containing protein 10
Names
F-box and WD-40 domain protein 10
testicular tissue protein Li 69
ubiquitin ligase specificity factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267585.2NP_001254514.1  F-box/WD repeat-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001254514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC107982, AL136822, AY729024, DB055860
    Consensus CDS
    CCDS11199.3
    UniProtKB/Swiss-Prot
    Q5XX13
    Related
    ENSP00000379025.4, ENST00000395665.9
    Conserved Domains (3) summary
    COG2319
    Location:416679
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:457493
    7WD40; WD40 repeat [structural motif]
  2. NM_001267586.2NP_001254515.1  F-box/WD repeat-containing protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC107982, AL136822, DB055860
    Consensus CDS
    CCDS58524.1
    UniProtKB/Swiss-Prot
    Q5XX13
    Related
    ENSP00000306937.4, ENST00000301938.4
    Conserved Domains (3) summary
    COG2319
    Location:416621
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418601
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:457493
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_051988.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC107982, AK310383, AL136822, DB055860
    Related
    ENST00000574478.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    18744024..18779349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523625.2XP_011521927.1  F-box/WD repeat-containing protein 10 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:467730
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:469704
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:508544
    7WD40; WD40 repeat [structural motif]
  2. XM_017024020.2XP_016879509.1  F-box/WD repeat-containing protein 10 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:467730
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:469704
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:508544
    7WD40; WD40 repeat [structural motif]
  3. XM_017024021.2XP_016879510.1  F-box/WD repeat-containing protein 10 isoform X3

  4. XM_011523626.3XP_011521928.1  F-box/WD repeat-containing protein 10 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:467740
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:469724
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:508544
    7WD40; WD40 repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031456.3: Suppressed sequence

    Description
    NM_031456.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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