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MYBBP1A MYB binding protein 1a [ Homo sapiens (human) ]

Gene ID: 10514, updated on 1-Jun-2020

Summary

Official Symbol
MYBBP1Aprovided by HGNC
Official Full Name
MYB binding protein 1aprovided by HGNC
Primary source
HGNC:HGNC:7546
See related
Ensembl:ENSG00000132382 MIM:604885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P160; PAP2; Pol5
Summary
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See MYBBP1A in Genome Data Viewer
Location:
17p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4538896..4555386, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4442191..4458921, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sphingolipid transporter 3 (putative) Neighboring gene uncharacterized LOC107985053 Neighboring gene sphingolipid transporter 2 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene thioredoxin pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, MYB binding protein 1a (MYBBP1A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
E-box binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoblast differentiation HDA PubMed 
positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NLS-dependent protein nuclear import complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myb-binding protein 1A
Names
MYB binding protein (P160) 1a
p53-activated protein-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047119.1 RefSeqGene

    Range
    5003..21483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105538.1NP_001099008.1  myb-binding protein 1A isoform 1

    See identical proteins and their annotated locations for NP_001099008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118754, AL136595, CB243989, DC346952
    Consensus CDS
    CCDS42238.1
    UniProtKB/Swiss-Prot
    Q9BQG0
    Related
    ENSP00000370968.2, ENST00000381556.6
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region
  2. NM_014520.4NP_055335.2  myb-binding protein 1A isoform 2

    See identical proteins and their annotated locations for NP_055335.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118754, BC000641, BC050546, BF111023, CB243989, DC346952
    Consensus CDS
    CCDS11046.1
    UniProtKB/Swiss-Prot
    Q9BQG0
    Related
    ENSP00000254718.4, ENST00000254718.8
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4538896..4555386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523616.2XP_011521918.1  myb-binding protein 1A isoform X2

    Conserved Domains (2) summary
    pfam04931
    Location:7584
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:9061006
    RCSD; RCSD region
  2. XM_024450536.1XP_024306304.1  myb-binding protein 1A isoform X1

    Conserved Domains (1) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi

RNA

  1. XR_002957950.1 RNA Sequence

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