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MYBBP1A MYB binding protein 1a [ Homo sapiens (human) ]

Gene ID: 10514, updated on 7-Sep-2023

Summary

Official Symbol
MYBBP1Aprovided by HGNC
Official Full Name
MYB binding protein 1aprovided by HGNC
Primary source
HGNC:HGNC:7546
See related
Ensembl:ENSG00000132382 MIM:604885; AllianceGenome:HGNC:7546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P160; PAP2; Pol5
Summary
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See MYBBP1A in Genome Data Viewer
Location:
17p13.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4538904..4555384, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4428802..4445280, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4442199..4458679, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) Neighboring gene uncharacterized LOC124903899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4384268-4385023 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4392946-4394145 Neighboring gene SPNS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4402340-4402975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4402976-4403610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4405882-4406398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4406399-4406914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4407104-4407604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4407605-4408105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4408166-4408835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4408836-4409504 Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4415494-4416140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4417497-4418154 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene thioredoxin pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, MYB binding protein 1a (MYBBP1A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ37886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables E-box binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_negative_effect regulation of G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of B-WICH complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NLS-dependent protein nuclear import complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myb-binding protein 1A
Names
MYB binding protein (P160) 1a
p53-activated protein-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047119.1 RefSeqGene

    Range
    5003..21483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105538.2NP_001099008.1  myb-binding protein 1A isoform 1

    See identical proteins and their annotated locations for NP_001099008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118754, AL136595, DC346952
    Consensus CDS
    CCDS42238.1
    UniProtKB/Swiss-Prot
    Q9BQG0
    UniProtKB/TrEMBL
    I3L1L3
    Related
    ENSP00000370968.2, ENST00000381556.6
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region
  2. NM_014520.4NP_055335.2  myb-binding protein 1A isoform 2

    See identical proteins and their annotated locations for NP_055335.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118754, BC000641, BC050546, BF111023, CB243989, DC346952
    Consensus CDS
    CCDS11046.1
    UniProtKB/Swiss-Prot
    Q86VM3, Q9BQG0, Q9BW49, Q9P0V5, Q9UF99
    UniProtKB/TrEMBL
    I3L1L3
    Related
    ENSP00000254718.4, ENST00000254718.9
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4538904..4555384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450536.2XP_024306304.1  myb-binding protein 1A isoform X1

    UniProtKB/TrEMBL
    I3L1L3
    Conserved Domains (1) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
  2. XM_011523616.3XP_011521918.1  myb-binding protein 1A isoform X2

    UniProtKB/TrEMBL
    I3L1L3
    Conserved Domains (2) summary
    pfam04931
    Location:7584
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:9061006
    RCSD; RCSD region
  3. XM_047435119.1XP_047291075.1  myb-binding protein 1A isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4428802..4445280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314704.1XP_054170679.1  myb-binding protein 1A isoform X1

    UniProtKB/TrEMBL
    I3L1L3
  2. XM_054314705.1XP_054170680.1  myb-binding protein 1A isoform X2

    UniProtKB/TrEMBL
    I3L1L3
  3. XM_054314706.1XP_054170681.1  myb-binding protein 1A isoform X3