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MYBBP1A MYB binding protein 1a [ Homo sapiens (human) ]

Gene ID: 10514, updated on 5-Sep-2021

Summary

Official Symbol
MYBBP1Aprovided by HGNC
Official Full Name
MYB binding protein 1aprovided by HGNC
Primary source
HGNC:HGNC:7546
See related
Ensembl:ENSG00000132382 MIM:604885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P160; PAP2; Pol5
Summary
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See MYBBP1A in Genome Data Viewer
Location:
17p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4538904..4555384, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4442199..4458679, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sphingolipid transporter 3 (putative) Neighboring gene SPNS2 antisense RNA 1 Neighboring gene sphingolipid transporter 2 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene thioredoxin pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify MYB binding protein 1a (MYBBP1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, MYB binding protein 1a (MYBBP1A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables E-box binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myb-binding protein 1A
Names
MYB binding protein (P160) 1a
p53-activated protein-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047119.1 RefSeqGene

    Range
    5003..21483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105538.2NP_001099008.1  myb-binding protein 1A isoform 1

    See identical proteins and their annotated locations for NP_001099008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118754, AL136595, DC346952
    Consensus CDS
    CCDS42238.1
    UniProtKB/Swiss-Prot
    Q9BQG0
    Related
    ENSP00000370968.2, ENST00000381556.6
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region
  2. NM_014520.4NP_055335.2  myb-binding protein 1A isoform 2

    See identical proteins and their annotated locations for NP_055335.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC118754, BC000641, BC050546, BF111023, CB243989, DC346952
    Consensus CDS
    CCDS11046.1
    UniProtKB/Swiss-Prot
    Q9BQG0
    Related
    ENSP00000254718.4, ENST00000254718.9
    Conserved Domains (2) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:11581258
    RCSD; RCSD region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4538904..4555384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523616.2XP_011521918.1  myb-binding protein 1A isoform X2

    Conserved Domains (2) summary
    pfam04931
    Location:7584
    DNA_pol_phi; DNA polymerase phi
    pfam05177
    Location:9061006
    RCSD; RCSD region
  2. XM_024450536.1XP_024306304.1  myb-binding protein 1A isoform X1

    Conserved Domains (1) summary
    pfam04931
    Location:72836
    DNA_pol_phi; DNA polymerase phi

RNA

  1. XR_002957950.1 RNA Sequence

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