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SEMA4B semaphorin 4B [ Homo sapiens (human) ]

Gene ID: 10509, updated on 3-Jun-2018
Official Symbol
SEMA4Bprovided by HGNC
Official Full Name
semaphorin 4Bprovided by HGNC
Primary source
HGNC:HGNC:10730
See related
Ensembl:ENSG00000185033 MIM:617029; Vega:OTTHUMG00000172096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SemC; SEMAC
Expression
Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues See more
Orthologs
See SEMA4B in Genome Data Viewer
Location:
15q26.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (90184920..90229660)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90727985..90772897)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NADP(+)) 2, mitochondrial Neighboring gene IDH2 divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene calcium and integrin binding 1 Neighboring gene tubulin tyrosine ligase like 13, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1745, MGC131831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
semaphorin-4B
Names
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324029.1NP_001310958.1  semaphorin-4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091167
  2. NM_001324030.1NP_001310959.1  semaphorin-4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091167
    Conserved Domains (3) summary
    cd05872
    Location:438521
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    pfam01437
    Location:369415
    PSI; Plexin repeat
    cl15693
    Location:1368
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. NM_001324031.1NP_001310960.1  semaphorin-4B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091167
  4. NM_001324032.1NP_001310961.1  semaphorin-4B isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091167
  5. NM_001324033.1NP_001310962.1  semaphorin-4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091167
    Conserved Domains (3) summary
    cd05872
    Location:438521
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    pfam01437
    Location:369415
    PSI; Plexin repeat
    cl15693
    Location:1368
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  6. NM_001324034.1NP_001310963.1  semaphorin-4B isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091167
  7. NM_020210.3NP_064595.2  semaphorin-4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_064595.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS45347.1
    UniProtKB/Swiss-Prot
    Q9NPR2
    UniProtKB/TrEMBL
    J3KNP4
    Related
    ENSP00000332204.6, OTTHUMP00000247637, ENST00000332496.10, OTTHUMT00000416809
    Conserved Domains (3) summary
    cd05872
    Location:594677
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11257
    Location:61524
    Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
    pfam01437
    Location:525571
    PSI; Plexin repeat
  8. NM_198925.2NP_945119.1  semaphorin-4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_945119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate 5' UTR and transcription from an alternate promoter compared to variant 1. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS45347.1
    UniProtKB/Swiss-Prot
    Q9NPR2
    UniProtKB/TrEMBL
    J3KNP4
    Related
    ENSP00000394720.2, OTTHUMP00000247638, ENST00000411539.6, OTTHUMT00000416810
    Conserved Domains (3) summary
    cd05872
    Location:594677
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11257
    Location:61524
    Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
    pfam01437
    Location:525571
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    90184920..90229660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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