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SEMA6B semaphorin 6B [ Homo sapiens (human) ]

Gene ID: 10501, updated on 23-May-2020

Summary

Official Symbol
SEMA6Bprovided by HGNC
Official Full Name
semaphorin 6Bprovided by HGNC
Primary source
HGNC:HGNC:10739
See related
Ensembl:ENSG00000167680 MIM:608873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPM11; SEMAN; semaZ; SEMA-VIB; SEM-SEMA-Y
Summary
This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 18.7), spleen (RPKM 8.6) and 15 other tissues See more
Orthologs

Genomic context

See SEMA6B in Genome Data Viewer
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4542588..4581484, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4542600..4559771, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene perilipin 5 Neighboring gene leucine rich alpha-2-glycoprotein 1 Neighboring gene uncharacterized LOC105372249 Neighboring gene ribosomal protein S10 pseudogene Neighboring gene TNF alpha induced protein 8 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
semaphorin-6B
Names
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
semaphorin VIB
semaphorin Z
semaphorin-6Ba

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032108.4NP_115484.2  semaphorin-6B precursor

    See identical proteins and their annotated locations for NP_115484.2

    Status: REVIEWED

    Source sequence(s)
    BC142617, DA818632, DB257858
    Consensus CDS
    CCDS12131.1
    UniProtKB/Swiss-Prot
    Q9H3T3
    Related
    ENSP00000467290.1, ENST00000586582.6
    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525554
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4542588..4581484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527640.2XP_011525942.1  semaphorin-6B isoform X1

    See identical proteins and their annotated locations for XP_011525942.1

    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525560
    PSI; Plexin repeat
  2. XM_011527639.2XP_011525941.1  semaphorin-6B isoform X1

    See identical proteins and their annotated locations for XP_011525941.1

    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525560
    PSI; Plexin repeat
  3. XM_011527641.1XP_011525943.1  semaphorin-6B isoform X2

    Related
    ENSP00000465722.1, ENST00000586965.1
    Conserved Domains (1) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020241.2: Suppressed sequence

    Description
    NM_020241.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_133327.1: Suppressed sequence

    Description
    NM_133327.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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