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CEBPA CCAAT enhancer binding protein alpha [ Homo sapiens (human) ]

Gene ID: 1050, updated on 22-Sep-2022

Summary

Official Symbol
CEBPAprovided by HGNC
Official Full Name
CCAAT enhancer binding protein alphaprovided by HGNC
Primary source
HGNC:HGNC:1833
See related
Ensembl:ENSG00000245848 MIM:116897; AllianceGenome:HGNC:1833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEBP; C/EBP-alpha
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Orthologs
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Genomic context

See CEBPA in Genome Data Viewer
Location:
19q13.11
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (33299934..33302534, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (35819706..35822306, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33790840..33793440, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 3 Neighboring gene solute carrier family 7 member 10 Neighboring gene HNF1 motif-containing MPRA enhancer 13 Neighboring gene CEBPA divergent transcript Neighboring gene RPS3A pseudogene 50

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection increases basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA) in peptide-treated PBMCs PubMed
Nef nef Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5 PubMed
Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in integrated stress response signaling IC
Inferred by Curator
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in liver development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myeloid cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 
involved_in positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in urea cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of C/EBP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of CHOP-C/EBP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCAAT/enhancer-binding protein alpha
Names
CCAAT/enhancer binding protein (C/EBP), alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012022.1 RefSeqGene

    Range
    4961..7591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_456

mRNA and Protein(s)

  1. NM_001285829.2NP_001272758.1  CCAAT/enhancer-binding protein alpha isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (b, also known as C/EBP-30) represented in this RefSeq results from translation initiation at the third AUG start codon. Isoform b has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    UniProtKB/Swiss-Prot
    P49715
    Conserved Domains (1) summary
    cd14711
    Location:161221
    bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
  2. NM_001287424.2NP_001274353.1  CCAAT/enhancer-binding protein alpha isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (c, also known as extended) represented in this RefSeq results from translation initiation at the upstream GUG start codon. Isoform c is the longest isoform.
    Source sequence(s)
    AC008738
    UniProtKB/Swiss-Prot
    P49715
    Conserved Domains (1) summary
    cd14711
    Location:315375
    bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
  3. NM_001287435.2NP_001274364.1  CCAAT/enhancer-binding protein alpha isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (d) represented in this RefSeq results from translation initiation at the second AUG start codon. Isoform d has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    UniProtKB/Swiss-Prot
    P49715
    Conserved Domains (1) summary
    cd14711
    Location:266326
    bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
  4. NM_004364.5NP_004355.2  CCAAT/enhancer-binding protein alpha isoform a

    See identical proteins and their annotated locations for NP_004355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (a, also known as C/EBP-42) represented in this RefSeq results from translation initiation at the first AUG start codon. Isoform a has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    Consensus CDS
    CCDS54243.1
    UniProtKB/Swiss-Prot
    P49715, Q05CA4
    Related
    ENSP00000427514.1, ENST00000498907.3
    Conserved Domains (1) summary
    cd14711
    Location:280340
    bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    33299934..33302534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    35819706..35822306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)