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CARM1 coactivator associated arginine methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 10498, updated on 7-Jun-2020

Summary

Official Symbol
CARM1provided by HGNC
Official Full Name
coactivator associated arginine methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:23393
See related
Ensembl:ENSG00000142453 MIM:603934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRMT4
Summary
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues See more
Orthologs

Genomic context

See CARM1 in Genome Data Viewer
Location:
19p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10871553..10923078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10982253..11033453)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 38 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with coactivator-associated arginine methyltransferase 1 (CARM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding TAS
Traceable Author Statement
more info
PubMed 
histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 
histone methyltransferase activity (H3-R17 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
histone-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear receptor transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-arginine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
protein-arginine omega-N asymmetric methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
endochondral bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
histone H3-R17 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-R2 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone methylation IDA
Inferred from Direct Assay
more info
 
histone methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
 
regulation of growth plate cartilage chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of mRNA binding IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-arginine methyltransferase CARM1
Names
protein arginine N-methyltransferase 4
NP_001357017.1
NP_001357018.1
NP_954592.1
XP_011525940.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370088.1NP_001357017.1  histone-arginine methyltransferase CARM1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    Related
    ENSP00000340934.3, ENST00000344150.8
    Conserved Domains (3) summary
    cd02440
    Location:188283
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:184394
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam11531
    Location:34138
    CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
  2. NM_001370089.1NP_001357018.1  histone-arginine methyltransferase CARM1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    Conserved Domains (3) summary
    cd02440
    Location:153248
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:149359
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17171
    Location:33103
    PH-like; Pleckstrin homology-like domain
  3. NM_199141.2NP_954592.1  histone-arginine methyltransferase CARM1 isoform 1

    See identical proteins and their annotated locations for NP_954592.1

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    Consensus CDS
    CCDS12250.1
    UniProtKB/Swiss-Prot
    Q86X55
    Related
    ENSP00000325690.3, ENST00000327064.8
    Conserved Domains (3) summary
    pfam05185
    Location:172435
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam11531
    Location:34138
    CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
    pfam12847
    Location:184283
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10871553..10923078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527638.2XP_011525940.1  histone-arginine methyltransferase CARM1 isoform X2

    See identical proteins and their annotated locations for XP_011525940.1

    Conserved Domains (2) summary
    pfam05185
    Location:11274
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam12847
    Location:23122
    Methyltransf_18; Methyltransferase domain
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