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CARM1 coactivator associated arginine methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 10498, updated on 19-Sep-2024

Summary

Official Symbol
CARM1provided by HGNC
Official Full Name
coactivator associated arginine methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:23393
See related
Ensembl:ENSG00000142453 MIM:603934; AllianceGenome:HGNC:23393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRMT4
Summary
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues See more
Orthologs
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Genomic context

See CARM1 in Genome Data Viewer
Location:
19p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10871553..10923075)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10998565..11050086)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10982229..11033751)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10945386-10946023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10946661-10947297 Neighboring gene chromosome 19 open reading frame 38 Neighboring gene HIKESHI pseudogene 2 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10973529-10974377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13997 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10984976-10985476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10985477-10985977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13999 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10989664-10990506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10991348-10992190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10992191-10993032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993033-10993874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993875-10994715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11004683-11005484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11009921-11010538 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11015702-11015889 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11031708-11031887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11037946-11038648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11038649-11039349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10095 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11046750-11047081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:11048011-11048510 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14001 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11087822-11088514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11120526-11121026 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with coactivator-associated arginine methyltransferase 1 (CARM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding TAS
Traceable Author Statement
more info
PubMed 
enables histone H3R17 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3R17 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H3R2 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3R2 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3R2 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear receptor coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 
enables protein methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-arginine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein-arginine omega-N asymmetric methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-arginine methyltransferase CARM1
Names
protein arginine N-methyltransferase 4
NP_001357017.1
NP_001357018.1
NP_954592.1
XP_011525940.1
XP_047294014.1
XP_054175514.1
XP_054175515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370088.1NP_001357017.1  histone-arginine methyltransferase CARM1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    Consensus CDS
    CCDS92516.1
    UniProtKB/TrEMBL
    A0AA34QVH5
    Related
    ENSP00000340934.3, ENST00000344150.8
    Conserved Domains (3) summary
    cd02440
    Location:188283
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:184394
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam11531
    Location:34138
    CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
  2. NM_001370089.1NP_001357018.1  histone-arginine methyltransferase CARM1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    UniProtKB/TrEMBL
    A0AA34QVH5
    Conserved Domains (3) summary
    cd02440
    Location:153248
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    COG0500
    Location:149359
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17171
    Location:33103
    PH-like; Pleckstrin homology-like domain
  3. NM_199141.2NP_954592.1  histone-arginine methyltransferase CARM1 isoform 1

    See identical proteins and their annotated locations for NP_954592.1

    Status: VALIDATED

    Source sequence(s)
    AC007565, AC011442
    Consensus CDS
    CCDS12250.1
    UniProtKB/Swiss-Prot
    A6NN38, Q86X55
    UniProtKB/TrEMBL
    A0AA34QVH5
    Related
    ENSP00000325690.4, ENST00000327064.9
    Conserved Domains (3) summary
    pfam05185
    Location:172435
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam11531
    Location:34138
    CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
    pfam12847
    Location:184283
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10871553..10923075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438058.1XP_047294014.1  histone-arginine methyltransferase CARM1 isoform X1

    UniProtKB/TrEMBL
    A0AA34QVH5
  2. XM_011527638.3XP_011525940.1  histone-arginine methyltransferase CARM1 isoform X2

    See identical proteins and their annotated locations for XP_011525940.1

    Conserved Domains (2) summary
    pfam05185
    Location:11274
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam12847
    Location:23122
    Methyltransf_18; Methyltransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10998565..11050086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319539.1XP_054175514.1  histone-arginine methyltransferase CARM1 isoform X1

    UniProtKB/TrEMBL
    A0AA34QVH5
  2. XM_054319540.1XP_054175515.1  histone-arginine methyltransferase CARM1 isoform X2