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ENOX2 ecto-NOX disulfide-thiol exchanger 2 [ Homo sapiens (human) ]

Gene ID: 10495, updated on 11-Sep-2019

Summary

Official Symbol
ENOX2provided by HGNC
Official Full Name
ecto-NOX disulfide-thiol exchanger 2provided by HGNC
Primary source
HGNC:HGNC:2259
See related
Ensembl:ENSG00000165675 MIM:300282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APK1; tNOX; COVA1
Summary
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See ENOX2 in Genome Data Viewer
Location:
Xq26.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (130622330..130903317, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129757355..130037219, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373336 Neighboring gene GATA motif-containing MPRA enhancer 234 Neighboring gene chromosome 12 open reading frame 49 pseudogene Neighboring gene uncharacterized LOC105373338 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene Rho GTPase activating protein 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
ultradian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ecto-NOX disulfide-thiol exchanger 2
Names
APK1 antigen
cytosolic ovarian carcinoma antigen 1
ecto-NADPH oxidase disulfide-thiol exchanger 2
tumor-associated NADH oxidase
tumor-associated hydroquinone oxidase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012562.2 RefSeqGene

    Range
    4918..284856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281736.1NP_001268665.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

    See identical proteins and their annotated locations for NP_001268665.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
    Source sequence(s)
    AI540639, AK000353, BC108713, BC140874, DB128861
    Consensus CDS
    CCDS14627.1
    UniProtKB/Swiss-Prot
    Q16206
    UniProtKB/TrEMBL
    Q32ND0
    Related
    ENSP00000359973.1, ENST00000370935.5
    Conserved Domains (2) summary
    COG0724
    Location:90168
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:93176
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  2. NM_006375.3NP_006366.2  ecto-NOX disulfide-thiol exchanger 2 isoform a

    See identical proteins and their annotated locations for NP_006366.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
    Source sequence(s)
    AI540639, AK289837, BC140874, DB128861
    Consensus CDS
    CCDS14627.1
    UniProtKB/Swiss-Prot
    Q16206
    Related
    ENSP00000377890.1, ENST00000394363.5
    Conserved Domains (2) summary
    COG0724
    Location:90168
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:93176
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  3. NM_182314.2NP_872114.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

    See identical proteins and their annotated locations for NP_872114.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).
    Source sequence(s)
    AI540639, AK000353, AK289812, BC140874, DB128861
    Consensus CDS
    CCDS14626.1
    UniProtKB/Swiss-Prot
    Q16206
    Related
    ENSP00000337146.3, ENST00000338144.7
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    130622330..130903317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531245.2XP_011529547.1  ecto-NOX disulfide-thiol exchanger 2 isoform X2

    Conserved Domains (2) summary
    COG0724
    Location:182260
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:185268
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  2. XM_017029229.2XP_016884718.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

  3. XM_011531244.3XP_011529546.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

    Conserved Domains (2) summary
    COG0724
    Location:182260
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:185268
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  4. XM_011531247.2XP_011529549.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    See identical proteins and their annotated locations for XP_011529549.1

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  5. XM_005262354.4XP_005262411.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    See identical proteins and their annotated locations for XP_005262411.1

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  6. XM_017029226.2XP_016884715.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  7. XM_017029227.1XP_016884716.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  8. XM_011531251.2XP_011529553.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

    See identical proteins and their annotated locations for XP_011529553.1

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:90168
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:93176
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  9. XM_017029228.1XP_016884717.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    UniProtKB/Swiss-Prot
    Q16206
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
  10. XM_011531249.2XP_011529551.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    See identical proteins and their annotated locations for XP_011529551.1

    UniProtKB/Swiss-Prot
    Q16206
    Related
    ENSP00000359965.1, ENST00000370927.5
    Conserved Domains (2) summary
    COG0724
    Location:119197
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:122205
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
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