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VAT1 vesicle amine transport 1 [ Homo sapiens (human) ]

Gene ID: 10493, updated on 7-Jun-2020

Summary

Official Symbol
VAT1provided by HGNC
Official Full Name
vesicle amine transport 1provided by HGNC
Primary source
HGNC:HGNC:16919
See related
Ensembl:ENSG00000108828 MIM:604631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VATI
Summary
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 107.1), ovary (RPKM 104.4) and 25 other tissues See more
Orthologs

Genomic context

See VAT1 in Genome Data Viewer
Location:
17q21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43014607..43022385, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41166622..41174459, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 Neighboring gene interferon induced protein 35 Neighboring gene Rho family GTPase 2 Neighboring gene BRCA1 DNA repair associated Neighboring gene ribosomal protein L21 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of vesicle amine transport protein 1 homolog (VAT1) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of vesicle amine transport 1 (VAT1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20230

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptic vesicle membrane protein VAT-1 homolog
Names
membrane protein of cholinergic synaptic vesicles
vesicle amine transport protein 1 homolog (T. californica)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006373.4NP_006364.2  synaptic vesicle membrane protein VAT-1 homolog

    See identical proteins and their annotated locations for NP_006364.2

    Status: VALIDATED

    Source sequence(s)
    AC055866, AC135721
    Consensus CDS
    CCDS11451.1
    UniProtKB/Swiss-Prot
    Q99536
    UniProtKB/TrEMBL
    A0A024R1Z6
    Related
    ENSP00000347872.2, ENST00000355653.8
    Conserved Domains (2) summary
    cd08275
    Location:49387
    MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    COG0604
    Location:51387
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43014607..43022385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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