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LINC02210-CRHR1 LINC02210-CRHR1 readthrough [ Homo sapiens (human) ]

Gene ID: 104909134, updated on 1-Jun-2020

Summary

Official Symbol
LINC02210-CRHR1provided by HGNC
Official Full Name
LINC02210-CRHR1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:51483
See related
Ensembl:ENSG00000263715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGC57346-CRHR1; CRHR1-IT1-CRHR1
Summary
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
Expression
Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 23 other tissues See more

Genomic context

See LINC02210-CRHR1 in Genome Data Viewer
Location:
17q21.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45620346..45835828)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2 Neighboring gene ribosomal protein S26 pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 2210 Neighboring gene uncharacterized LOC105371802 Neighboring gene ADP ribosylation factor 2, pseudogene Neighboring gene uncharacterized LOC107985028 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene MAPT intronic transcript 1 Neighboring gene microtubule associated protein tau

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
CRHR1-IT1-CRHR1 protein
Names
CRHR1-IT1-CRHR1 readthrough

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256299.3NP_001243228.1  CRHR1-IT1-CRHR1 protein isoform 5

    See identical proteins and their annotated locations for NP_001243228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure, and it thus differs in the 5' UTR, initiates translation at a downstream in-frame start codon, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 6. The encoded isoform (5) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 6.
    Source sequence(s)
    AC217771, FJ543100
    UniProtKB/Swiss-Prot
    P34998
    UniProtKB/TrEMBL
    A0A024R9X9
    Related
    ENSP00000488912.1, ENST00000634540.1
    Conserved Domains (2) summary
    cd14964
    Location:1436
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1205
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001303016.1NP_001289945.1  CRHR1-IT1-CRHR1 protein isoform 6

    See identical proteins and their annotated locations for NP_001289945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longer isoform (6).
    Source sequence(s)
    AC217771, AK297590, FJ543100
    UniProtKB/Swiss-Prot
    P34998
    UniProtKB/TrEMBL
    B4DMR5
    Conserved Domains (1) summary
    pfam00002
    Location:15212
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45620346..45835828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    952322..1168458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    322470..537950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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