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CAP1 cyclase associated actin cytoskeleton regulatory protein 1 [ Homo sapiens (human) ]

Gene ID: 10487, updated on 7-Jun-2020

Summary

Official Symbol
CAP1provided by HGNC
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 1provided by HGNC
Primary source
HGNC:HGNC:20040
See related
Ensembl:ENSG00000131236 MIM:617801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; CAP1-PEN
Summary
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues See more
Orthologs

Genomic context

See CAP1 in Genome Data Viewer
Location:
1p34.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (40040240..40072648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40505912..40538321)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene uncharacterized LOC105378669 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized LOC105378671 Neighboring gene OAZ1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
ameboidal-type cell migration IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP, adenylate cyclase-associated protein 1
adenylate cyclase associated protein 1
testis secretory sperm-binding protein Li 218p

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105530.2NP_001099000.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    Related
    ENSP00000361883.3, ENST00000372797.7
  2. NM_001330502.2NP_001317431.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    Related
    ENSP00000344832.3, ENST00000340450.7
  3. NM_001350475.2NP_001337404.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  4. NM_001350476.2NP_001337405.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  5. NM_001350477.3NP_001337406.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    Related
    ENSP00000361878.2, ENST00000372792.7
  6. NM_001350478.2NP_001337407.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  7. NM_001350479.2NP_001337408.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  8. NM_001350480.2NP_001337409.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  9. NM_001350481.2NP_001337410.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
  10. NM_001350482.2NP_001337411.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    Related
    ENSP00000361884.1, ENST00000372798.5
  11. NM_001350483.2NP_001337412.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    Related
    ENSP00000361888.1, ENST00000372802.5
  12. NM_001350484.2NP_001337413.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
  13. NM_001350485.2NP_001337414.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
  14. NM_006367.4NP_006358.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    Related
    ENSP00000361891.3, ENST00000372805.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    40040240..40072648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540515.1XP_011538817.1  adenylyl cyclase-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011538817.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:7292
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:323472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. XM_011540510.1XP_011538812.1  adenylyl cyclase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538812.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:7293
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:324473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  3. XM_017000069.1XP_016855558.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:7293
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:324473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
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