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SEC23A SEC23 homolog A, COPII component [ Homo sapiens (human) ]

Gene ID: 10484, updated on 6-Jul-2026
Official Symbol
SEC23Aprovided by HGNC
Official Full Name
SEC23 homolog A, COPII componentprovided by HGNC
Primary source
HGNC:HGNC:10701
See related
Ensembl:ENSG00000100934 MIM:610511; AllianceGenome:HGNC:10701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLSD; hSec23A
Summary
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See SEC23A in Genome Data Viewer
Location:
14q21.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (39031919..39103235, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (33220592..33291912, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39501123..39572439, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long independently transcribed non-coding RNA 639 Neighboring gene uncharacterized LOC105370457 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:39401304-39402503 Neighboring gene uncharacterized LOC102723516 Neighboring gene RIPPLY3 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39486106-39486616 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39486617-39487127 Neighboring gene Sharpr-MPRA regulatory region 2779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5686 Neighboring gene uncharacterized LOC105370459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39579989-39580506 Neighboring gene SEC23A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8285 Neighboring gene peptidylprolyl isomerase A pseudogene 4 Neighboring gene gem nuclear organelle associated protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion. Boyadjiev SA, et al. Clin Genet, 2011 Aug. PMID 21039434, Free PMC Article
  2. Endoplasmic reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs. Amodio G, et al. FEBS Lett, 2013 Oct 1. PMID 23994533
  3. SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop. Cheng Q, et al. J Exp Clin Cancer Res, 2023 Sep 5. PMID 37670384, Free PMC Article
  4. Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients. Wang Q, et al. BMC Med Genomics, 2023 Oct 12. PMID 37828500, Free PMC Article
  5. A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21. Boyadjiev SA, et al. Hum Genet, 2003 Jul. PMID 12677423

See all (155) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients.
    Title: Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients.
  2. SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.
    Title: SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.
  3. MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.
    Title: MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.
  4. Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.
    Title: Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.
  5. identified Sec23a, a gene target of miR-200c, suppresses miR-200c augmented oligometastatic to polymetastatic progression via its secretome. Firstly, miR-200c over-expression and Sec23a interference accelerated oligometastatic to polymetatic progression. Secondly, Sec23a functions downstream of miR-200c.
    Title: Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression.
  6. This larger GWAS yields two loci harboring genome-wide significant variants affecting serum 25-hydroxyvitamin D levels (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1).
    Title: Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
  7. these data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes.
    Title: Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.
  8. Mutation on serine207 of Sec23A protein changes Unc-51 like kinase 1(ULK 1) targeted phosphorylation. During elevated autophagy, induced by amino acid starvation, rapamycin, or overexpression of ULK1,phosphorylation of Sec23A reduced the interaction between vesicular transport proteins Sec23A and Sec31A.
    Title: ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic.
  9. Data indicate that vesicular transport protein SEC23A as a target of miR-375.
    Title: MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib.
  10. findings suggest that miR-21 promoted proliferation, migration, and invasion of colorectal cancer cells in vitro by down regulating the expression of Sec23A
    Title: MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Craniolenticulosutural dysplasia
MedGen: C1843042 OMIM: 607812 GeneReviews: Not available
not available

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26267

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IEA
Inferred from Electronic Annotation
more info
  
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in COPII-coated vesicle cargo loading IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endocytic recycling IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in COPII-coated ER to Golgi transport vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ER to Golgi transport vesicle membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein transport protein Sec23A
Names
SEC23 homolog A, COPII coat complex component
SEC23-related protein A
Sec23 homolog A, coat complex II component

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012157.1 RefSeqGene

    Range
    4999..76315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001446205.1 → NP_001433134.1  protein transport protein Sec23A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL109628
    UniProtKB/TrEMBL
    A0ACI8Q5U6, A0ACI8UCC1

  2. NM_006364.4 → NP_006355.2  protein transport protein Sec23A isoform 1

    See identical proteins and their annotated locations for NP_006355.2

    Status: REVIEWED

    Source sequence(s)
    BC036649, BM541968, DC335582, X97064
    Consensus CDS
    CCDS9668.1
    UniProtKB/Swiss-Prot
    B2R5P4, B3KXI2, Q15436, Q8NE16
    UniProtKB/TrEMBL
    A0ACI8UCC1
    Related
    ENSP00000306881.6, ENST00000307712.11
    Conserved Domains (1) summary
    PLN00162
    Location:12 → 763
    PLN00162; transport protein sec23; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    39031919..39103235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267262.2 → XP_005267319.1  

    Related
    ENSP00000527801.1, ENST00000857742.1
    Conserved Domains (6) summary
    cd11287
    Location:634 → 754
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 787
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 388
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:522 → 639
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:401 → 504
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  2. XM_011536355.4 → XP_011534657.1  protein transport protein Sec23A isoform X2

    UniProtKB/TrEMBL
    A0ACI8UCC1
    Conserved Domains (6) summary
    cd11287
    Location:634 → 754
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 762
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 388
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:522 → 639
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:401 → 504
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  3. XM_017020928.3 → XP_016876417.1  protein transport protein Sec23A isoform X3

    UniProtKB/TrEMBL
    A0ACI8UCC1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    33220592..33291912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375271.1 → XP_054231246.1  

  2. XM_054375272.1 → XP_054231247.1  protein transport protein Sec23A isoform X2

    UniProtKB/TrEMBL
    A0ACI8UCC1

  3. XM_054375273.1 → XP_054231248.1  protein transport protein Sec23A isoform X3

    UniProtKB/TrEMBL
    A0ACI8UCC1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15436.2 GenPept UniProtKB/Swiss-Prot:Q15436

Gene LinkOut

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