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SEC23A Sec23 homolog A, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 10484, updated on 24-Nov-2020

Summary

Official Symbol
SEC23Aprovided by HGNC
Official Full Name
Sec23 homolog A, COPII coat complex componentprovided by HGNC
Primary source
HGNC:HGNC:10701
See related
Ensembl:ENSG00000100934 MIM:610511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLSD; hSec23A
Summary
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues See more
Orthologs

Genomic context

See SEC23A in Genome Data Viewer
Location:
14q21.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (39031919..39103235, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39501123..39572447, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 639 Neighboring gene uncharacterized LOC105370457 Neighboring gene uncharacterized LOC102723516 Neighboring gene RIPPLY3 pseudogene 1 Neighboring gene uncharacterized LOC105370459 Neighboring gene SEC23A antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 4 Neighboring gene gem nuclear organelle associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26267

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi transport vesicle membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein transport protein Sec23A
Names
SEC23-related protein A
Sec23 homolog A, coat complex II component

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012157.1 RefSeqGene

    Range
    4999..76315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006364.4NP_006355.2  protein transport protein Sec23A

    See identical proteins and their annotated locations for NP_006355.2

    Status: REVIEWED

    Source sequence(s)
    BC036649, BM541968, DC335582, X97064
    Consensus CDS
    CCDS9668.1
    UniProtKB/Swiss-Prot
    Q15436
    Related
    ENSP00000306881.6, ENST00000307712.11
    Conserved Domains (6) summary
    cd11287
    Location:610730
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12763
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126388
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:5897
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:522615
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:401504
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    39031919..39103235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267262.2XP_005267319.1  protein transport protein Sec23A isoform X1

    Conserved Domains (6) summary
    cd11287
    Location:634754
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12787
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126388
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:5897
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:522639
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:401504
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
  2. XM_011536355.3XP_011534657.1  protein transport protein Sec23A isoform X2

    Conserved Domains (6) summary
    cd11287
    Location:634754
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12762
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126388
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:5897
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:522639
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:401504
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
  3. XM_017020928.2XP_016876417.1  protein transport protein Sec23A isoform X3

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