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Cbll1 Casitas B-lineage lymphoma-like 1 [ Mus musculus (house mouse) ]

Gene ID: 104836, updated on 8-Dec-2018

Summary

Official Symbol
Cbll1provided by MGI
Official Full Name
Casitas B-lineage lymphoma-like 1provided by MGI
Primary source
MGI:MGI:2144842
See related
Ensembl:ENSMUSG00000020659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hakai; AI467391; c-Cbl-like
Expression
Ubiquitous expression in testis adult (RPKM 6.4), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
Orthologs

Genomic context

See Cbll1 in Genome Data Viewer
Location:
12; 12 A2
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (31484829..31500543, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32171761..32184405, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 13 pseudogene Neighboring gene solute carrier family 26, member 3 Neighboring gene predicted gene, 40362 Neighboring gene solute carrier family 26, member 4 Neighboring gene B cell receptor associated protein 29

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
mRNA methylation ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Hakai
Names
E-cadherin binding protein E7
RING-type E3 ubiquitin transferase Hakai
c-Cbl-like protein 1
casitas B-lineage lymphoma-transforming sequence-like protein 1
NP_001240776.1
NP_001240777.1
NP_598809.1
XP_006514999.1
XP_006515000.1
XP_006515001.1
XP_006515002.1
XP_006515003.1
XP_006515004.1
XP_006515005.1
XP_017170419.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253847.1NP_001240776.1  E3 ubiquitin-protein ligase Hakai isoform 1

    See identical proteins and their annotated locations for NP_001240776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK051737, CR974423
    Consensus CDS
    CCDS56834.1
    UniProtKB/Swiss-Prot
    Q9JIY2
    Related
    ENSMUSP00000099038.3, ENSMUST00000101499.9
    Conserved Domains (1) summary
    pfam13923
    Location:109148
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  2. NM_001253848.1NP_001240777.1  E3 ubiquitin-protein ligase Hakai isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an segment in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    CR974423
    Consensus CDS
    CCDS56835.1
    UniProtKB/TrEMBL
    A0A087WPK1
    Related
    ENSMUSP00000139809.2, ENSMUST00000188326.2
    Conserved Domains (1) summary
    pfam13923
    Location:105144
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  3. NM_134048.2NP_598809.1  E3 ubiquitin-protein ligase Hakai isoform 2

    See identical proteins and their annotated locations for NP_598809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BB651673, CR974423
    UniProtKB/Swiss-Prot
    Q9JIY2
    UniProtKB/TrEMBL
    A0A087WSE1
    Related
    ENSMUSP00000141007.2, ENSMUST00000185739.7
    Conserved Domains (1) summary
    pfam13923
    Location:108147
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    31484829..31500543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514939.3XP_006515002.1  E3 ubiquitin-protein ligase Hakai isoform X4

    Conserved Domains (1) summary
    pfam13923
    Location:116155
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  2. XM_006514938.3XP_006515001.1  E3 ubiquitin-protein ligase Hakai isoform X3

    Conserved Domains (1) summary
    pfam13923
    Location:117156
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  3. XM_006514937.3XP_006515000.1  E3 ubiquitin-protein ligase Hakai isoform X2

    Conserved Domains (1) summary
    pfam13923
    Location:119158
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  4. XM_006514936.3XP_006514999.1  E3 ubiquitin-protein ligase Hakai isoform X1

    Conserved Domains (1) summary
    pfam13923
    Location:120159
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  5. XM_006514941.2XP_006515004.1  E3 ubiquitin-protein ligase Hakai isoform X6

    Conserved Domains (1) summary
    pfam13923
    Location:105144
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  6. XM_006514940.2XP_006515003.1  E3 ubiquitin-protein ligase Hakai isoform X5

    UniProtKB/TrEMBL
    A0A1X7SB71
    Related
    ENSMUSP00000063266.7, ENSMUST00000064240.13
    Conserved Domains (1) summary
    pfam13923
    Location:106145
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  7. XM_006514942.3XP_006515005.1  E3 ubiquitin-protein ligase Hakai isoform X7

    Conserved Domains (1) summary
    pfam13923
    Location:5998
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  8. XM_017314930.1XP_017170419.1  E3 ubiquitin-protein ligase Hakai isoform X8

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