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Ptpn23 protein tyrosine phosphatase, non-receptor type 23 [ Mus musculus (house mouse) ]

Gene ID: 104831, updated on 12-Aug-2019

Summary

Official Symbol
Ptpn23provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 23provided by MGI
Primary source
MGI:MGI:2144837
See related
Ensembl:ENSMUSG00000036057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI462446; PTP-TD14
Expression
Ubiquitous expression in adrenal adult (RPKM 17.6), limb E14.5 (RPKM 12.4) and 28 other tissues See more
Orthologs

Genomic context

See Ptpn23 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
26
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110385084..110408210, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110287593..110310714, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene SREBF chaperone Neighboring gene kelch-like 18 Neighboring gene neutrophilic granule protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 23
NP_001074512.1
XP_011241233.1
XP_030099856.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081043.1NP_001074512.1  tyrosine-protein phosphatase non-receptor type 23

    See identical proteins and their annotated locations for NP_001074512.1

    Status: VALIDATED

    Source sequence(s)
    BC059902, BY008138, CA325506, CF538443, CF734421
    Consensus CDS
    CCDS40780.1
    UniProtKB/Swiss-Prot
    Q6PB44
    Related
    ENSMUSP00000039580.7, ENSMUST00000040021.11
    Conserved Domains (5) summary
    cd09234
    Location:362702
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd09239
    Location:2357
    BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd00047
    Location:12761505
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:12761506
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam13949
    Location:417703
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p6 C57BL/6J

    Range
    110385084..110408210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242931.2XP_011241233.1  tyrosine-protein phosphatase non-receptor type 23 isoform X2

    Conserved Domains (5) summary
    cd09234
    Location:169509
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd00047
    Location:10831312
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:10831313
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam13949
    Location:224510
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
    cl14649
    Location:1164
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  2. XM_030243996.1XP_030099856.1  tyrosine-protein phosphatase non-receptor type 23 isoform X1

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