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Ptpn23 protein tyrosine phosphatase, non-receptor type 23 [ Mus musculus (house mouse) ]

Gene ID: 104831, updated on 12-May-2024

Summary

Official Symbol
Ptpn23provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 23provided by MGI
Primary source
MGI:MGI:2144837
See related
Ensembl:ENSMUSG00000036057 AllianceGenome:MGI:2144837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP-TD14
Summary
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; positive regulation of adherens junction organization; and positive regulation of transport. Predicted to act upstream of or within cell projection organization and protein transport. Predicted to be located in ciliary basal body; early endosome; and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; gonad; respiratory system epithelium; and skin. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 17.6), limb E14.5 (RPKM 12.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ptpn23 in Genome Data Viewer
Location:
9 F2; 9 59.92 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110214152..110237278, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110385084..110408210, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene STARR-seq mESC enhancer starr_25259 Neighboring gene SREBF chaperone Neighboring gene STARR-seq mESC enhancer starr_25260 Neighboring gene STARR-positive B cell enhancer ABC_E6807 Neighboring gene kelch-like 18 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 23
NP_001074512.1
XP_011241233.1
XP_030099856.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081043.1NP_001074512.1  tyrosine-protein phosphatase non-receptor type 23

    See identical proteins and their annotated locations for NP_001074512.1

    Status: VALIDATED

    Source sequence(s)
    BC059902, BY008138, CA325506, CF538443, CF734421
    Consensus CDS
    CCDS40780.1
    UniProtKB/Swiss-Prot
    Q69ZJ0, Q6PB44, Q8R1Z5, Q923E6
    Related
    ENSMUSP00000039580.8, ENSMUST00000040021.12
    Conserved Domains (5) summary
    cd09234
    Location:362702
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd09239
    Location:2357
    BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    cd00047
    Location:12761505
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:12761506
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam13949
    Location:417703
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110214152..110237278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242931.3XP_011241233.1  tyrosine-protein phosphatase non-receptor type 23 isoform X2

    Conserved Domains (4) summary
    cd09234
    Location:169509
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PHA03247
    Location:540946
    PHA03247; large tegument protein UL36; Provisional
    cd14539
    Location:11061310
    PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23
    cl14649
    Location:1164
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  2. XM_030243996.2XP_030099856.1  tyrosine-protein phosphatase non-receptor type 23 isoform X1

    Conserved Domains (4) summary
    cd09234
    Location:279619
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PHA03247
    Location:6501056
    PHA03247; large tegument protein UL36; Provisional
    cd14539
    Location:12161420
    PTP-N23; PTP-like domain of tyrosine-protein phosphatase non-receptor type 23
    cl14649
    Location:1274
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains