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EIF3M eukaryotic translation initiation factor 3 subunit M [ Homo sapiens (human) ]

Gene ID: 10480, updated on 25-Nov-2021

Summary

Official Symbol
EIF3Mprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Mprovided by HGNC
Primary source
HGNC:HGNC:24460
See related
Ensembl:ENSG00000149100 MIM:609641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B5; GA17; PCID1; TANGO7; hfl-B5
Summary
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3M in Genome Data Viewer
Location:
11p13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (32583816..32606264)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32605377..32627810)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene WT1 transcription factor Neighboring gene WT1 antisense RNA Neighboring gene protein GVQW2-like Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene proline rich and Gla domain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit M (EIF3M), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF3M is decreased by RRE PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit M (EIF3M) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ29030

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit M
Names
B5 receptor
PCI domain containing 1 (herpesvirus entry mediator)
PCI domain-containing protein 1
dendritic cell protein
fetal lung protein B5
transport and golgi organization 7 homolog
NP_001294858.1
NP_006351.2
XP_011518142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307929.2NP_001294858.1  eukaryotic translation initiation factor 3 subunit M isoform 2

    See identical proteins and their annotated locations for NP_001294858.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK292139, AK304378, AL078477, AV713889, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS76392.1
    UniProtKB/Swiss-Prot
    Q7L2H7
    Related
    ENSP00000436787.1, ENST00000524896.5
    Conserved Domains (1) summary
    smart00088
    Location:137225
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
  2. NM_006360.6NP_006351.2  eukaryotic translation initiation factor 3 subunit M isoform 1

    See identical proteins and their annotated locations for NP_006351.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304378, AL078477, BC019103, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS7880.1
    UniProtKB/Swiss-Prot
    Q7L2H7
    Related
    ENSP00000436049.1, ENST00000531120.6
    Conserved Domains (1) summary
    smart00088
    Location:269357
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    32583816..32606264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519840.3XP_011518142.1  eukaryotic translation initiation factor 3 subunit M isoform X1

    See identical proteins and their annotated locations for XP_011518142.1

    Conserved Domains (1) summary
    smart00088
    Location:206294
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
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