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EIF3M eukaryotic translation initiation factor 3 subunit M [ Homo sapiens (human) ]

Gene ID: 10480, updated on 17-Jun-2024

Summary

Official Symbol
EIF3Mprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Mprovided by HGNC
Primary source
HGNC:HGNC:24460
See related
Ensembl:ENSG00000149100 MIM:609641; AllianceGenome:HGNC:24460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B5; GA17; PCID1; TANGO7; hfl-B5
Summary
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3M in Genome Data Viewer
Location:
11p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32583831..32606264)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32719345..32741774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32605377..32627810)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 88 Neighboring gene HCNE2 enhancer upstream of PAX6 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32380174-32380395 Neighboring gene WT1 3' enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3221 Neighboring gene WT1 intron 3 regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32449464-32450078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:32450079-32450691 Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene WT1 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1244 silencer Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit M (EIF3M), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF3M is decreased by RRE PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit M (EIF3M) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ29030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit M
Names
B5 receptor
PCI domain containing 1 (herpesvirus entry mediator)
PCI domain-containing protein 1
dendritic cell protein
fetal lung protein B5
transport and golgi organization 7 homolog
NP_001294858.1
NP_006351.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307929.2NP_001294858.1  eukaryotic translation initiation factor 3 subunit M isoform 2

    See identical proteins and their annotated locations for NP_001294858.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK292139, AK304378, AL078477, AV713889, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS76392.1
    UniProtKB/TrEMBL
    H0YCQ8
    Related
    ENSP00000436787.1, ENST00000524896.5
    Conserved Domains (1) summary
    smart00088
    Location:137225
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
  2. NM_006360.6NP_006351.2  eukaryotic translation initiation factor 3 subunit M isoform 1

    See identical proteins and their annotated locations for NP_006351.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304378, AL078477, BC019103, BE935691, CK002866, DB479224
    Consensus CDS
    CCDS7880.1
    UniProtKB/Swiss-Prot
    A8K7X4, B4E2Q4, O60735, Q2F836, Q53HL6, Q7L2H7, Q9BXW1
    Related
    ENSP00000436049.1, ENST00000531120.6
    Conserved Domains (1) summary
    smart00088
    Location:269357
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    32583831..32606264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    32719345..32741774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)