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ATP5PD ATP synthase peripheral stalk subunit d [ Homo sapiens (human) ]

Gene ID: 10476, updated on 12-Oct-2019

Summary

Official Symbol
ATP5PDprovided by HGNC
Official Full Name
ATP synthase peripheral stalk subunit dprovided by HGNC
Primary source
HGNC:HGNC:845
See related
Ensembl:ENSG00000167863 MIM:618121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPQ; APT5H; ATP5H
Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in heart (RPKM 220.3), kidney (RPKM 160.7) and 25 other tissues See more
Orthologs

Genomic context

See ATP5PD in Genome Data Viewer
Location:
17q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75038863..75046969, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73034955..73043074, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon CCT) 2-1 Neighboring gene tRNA-Arg (anticodon TCG) 3-1 Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene RNA, 7SL, cytoplasmic 573, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3986 Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene solute carrier family 16 member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d (ATP5H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase, stator stalk IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP synthase subunit d, mitochondrial
Names
ATP synthase D chain, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d
ATP synthase, H+ transporting, mitochondrial F1F0, subunit d
ATP synthase, H+ transporting, mitochondrial Fo complex subunit D
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATPase subunit d
My032 protein
NP_001003785.1
NP_006347.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003785.2NP_001003785.1  ATP synthase subunit d, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001003785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AA608885, BC032245
    Consensus CDS
    CCDS32727.1
    UniProtKB/Swiss-Prot
    O75947
    Related
    ENSP00000344230.4, ENST00000344546.8
    Conserved Domains (1) summary
    pfam05873
    Location:3131
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
  2. NM_006356.3NP_006347.1  ATP synthase subunit d, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_006347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and it encodes the longer isoform a.
    Source sequence(s)
    AA608885, BC029392, BC032245, BC038092
    Consensus CDS
    CCDS11712.1
    UniProtKB/Swiss-Prot
    O75947
    UniProtKB/TrEMBL
    A0PJH2
    Related
    ENSP00000301587.4, ENST00000301587.9
    Conserved Domains (1) summary
    pfam05873
    Location:3155
    Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75038863..75046969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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