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TADA3 transcriptional adaptor 3 [ Homo sapiens (human) ]

Gene ID: 10474, updated on 7-Jun-2020

Summary

Official Symbol
TADA3provided by HGNC
Official Full Name
transcriptional adaptor 3provided by HGNC
Primary source
HGNC:HGNC:19422
See related
Ensembl:ENSG00000171148 MIM:602945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA3; NGG1; hADA3; STAF54; TADA3L
Summary
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in testis (RPKM 21.9), ovary (RPKM 20.9) and 25 other tissues See more
Orthologs

Genomic context

See TADA3 in Genome Data Viewer
Location:
3p25.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9779964..9793011, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9821648..9834695, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20221, FLJ21329

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
histone H3 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular estrogen receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of tubulin deacetylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional adapter 3
Names
ADA3 homolog
ADA3-like protein
alteration/deficiency in activation 3
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278270.1NP_001265199.1  transcriptional adapter 3 isoform a

    See identical proteins and their annotated locations for NP_001265199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AA602644, AK292264, BC009240, BC013433
    Consensus CDS
    CCDS2583.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A8K899
    Related
    ENSP00000393471.1, ENST00000440161.5
    Conserved Domains (1) summary
    pfam10198
    Location:309422
    Ada3; Histone acetyltransferases subunit 3
  2. NM_006354.3NP_006345.1  transcriptional adapter 3 isoform a

    See identical proteins and their annotated locations for NP_006345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AA602644, AC022382, AK292264, BC009240, BC013433, BM560517, DB032623
    Consensus CDS
    CCDS2583.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A8K899
    Related
    ENSP00000307684.2, ENST00000301964.6
    Conserved Domains (1) summary
    pfam10198
    Location:309422
    Ada3; Histone acetyltransferases subunit 3
  3. NM_133480.2NP_597814.1  transcriptional adapter 3 isoform b

    See identical proteins and their annotated locations for NP_597814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1, that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes isoform b which is shorter at the C-terminus, compared to isoform a.
    Source sequence(s)
    AC022382, AK292264, BC009240, BM560517, DB032623
    Consensus CDS
    CCDS2584.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A0A024R2D7, A8K899
    Related
    ENSP00000343649.2, ENST00000343450.2
    Conserved Domains (1) summary
    pfam10198
    Location:309368
    Ada3; Histone acetyltransferases subunit 3

RNA

  1. NR_103488.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons and uses alternate splice sites in the 5' terminal exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA602644, AC022382, AK292264, BC013433, BG477633

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9779964..9793011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133481.1: Suppressed sequence

    Description
    NM_133481.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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