HMGN4 high mobility group nucleosomal binding domain 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HMGN4provided by HGNC
Official Full Name: high mobility group nucleosomal binding domain 4provided by HGNC
Primary source: HGNC:HGNC:4989
See related: Ensembl:ENSG00000182952 AllianceGenome:HGNC:4989
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NHC; HMG17L3
Summary: The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
Expression: Ubiquitous expression in lymph node (RPKM 30.6), thyroid (RPKM 30.3) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 6p22.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (26538366..26546933)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (26406761..26415326)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (26538594..26547161)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HMGN4 plays a key role in STAT3-mediated oncogenesis of triple-negative breast cancer.
Title: HMGN4 plays a key role in STAT3-mediated oncogenesis of triple-negative breast cancer.
HMGN4 may serve as an additional diagnostic marker.
Title: Elevated HMGN4 expression potentiates thyroid tumorigenesis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68775 (e-PCR)
- UniSTS:71426

WI-13558 (e-PCR)
- UniSTS:22323

SHGC-35158 (e-PCR)
- UniSTS:6740

G54070 (e-PCR)
- UniSTS:109452

D6S2358 (e-PCR)
- UniSTS:21901

RH46615 (e-PCR)
- UniSTS:42229

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high mobility group nucleosome-binding domain-containing protein 4

Names: high mobility group protein N4; high-mobility group (nonhistone chromosomal) protein 17-like 3; high-mobility group protein 17-like 3; non-histone chromosomal protein HMG-17-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.