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HMGN4 high mobility group nucleosomal binding domain 4 [ Homo sapiens (human) ]

Gene ID: 10473, updated on 27-Nov-2024

Summary

Official Symbol
HMGN4provided by HGNC
Official Full Name
high mobility group nucleosomal binding domain 4provided by HGNC
Primary source
HGNC:HGNC:4989
See related
Ensembl:ENSG00000182952 AllianceGenome:HGNC:4989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHC; HMG17L3
Summary
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in lymph node (RPKM 30.6), thyroid (RPKM 30.3) and 25 other tissues See more
Orthologs
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Genomic context

See HMGN4 in Genome Data Viewer
Location:
6p22.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26538366..26546933)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26406761..26415326)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26538594..26547161)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:26537578-26537871 Neighboring gene tRNA-Arg (anticodon ACG) 1-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17013 Neighboring gene tRNA-Val (anticodon CAC) 1-6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26549364-26550318 Neighboring gene HMGN4-LOC105374988 intergenic CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24247 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1175 Neighboring gene tRNA-Ala (anticodon CGC) 1-1 Neighboring gene tRNA-Ile (anticodon AAT) 5-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC5145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
high mobility group nucleosome-binding domain-containing protein 4
Names
high mobility group protein N4
high-mobility group (nonhistone chromosomal) protein 17-like 3
high-mobility group protein 17-like 3
non-histone chromosomal protein HMG-17-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006353.3NP_006344.1  high mobility group nucleosome-binding domain-containing protein 4

    See identical proteins and their annotated locations for NP_006344.1

    Status: REVIEWED

    Source sequence(s)
    AL121936
    Consensus CDS
    CCDS4615.1
    UniProtKB/Swiss-Prot
    B2R4I6, O00479, Q53XL9
    Related
    ENSP00000366798.1, ENST00000377575.3
    Conserved Domains (1) summary
    pfam01101
    Location:188
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26538366..26546933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791780.1 Reference GRCh38.p14 PATCHES

    Range
    84546..93113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    26406761..26415326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)