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HMGN4 high mobility group nucleosomal binding domain 4 [ Homo sapiens (human) ]

Gene ID: 10473, updated on 1-Aug-2020

Summary

Official Symbol
HMGN4provided by HGNC
Official Full Name
high mobility group nucleosomal binding domain 4provided by HGNC
Primary source
HGNC:HGNC:4989
See related
Ensembl:ENSG00000182952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHC; HMG17L3
Summary
The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in lymph node (RPKM 30.6), thyroid (RPKM 30.3) and 25 other tissues See more
Orthologs

Genomic context

See HMGN4 in Genome Data Viewer
Location:
6p22.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26538347..26546933)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26538572..26547165)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon ACG) 1-2 Neighboring gene tRNA-Val (anticodon CAC) 1-6 Neighboring gene HMGN4-LOC105374988 intergenic CAGE-defined low expression enhancer Neighboring gene CRISPRi-validated cis-regulatory element chr6.1175 Neighboring gene tRNA-Ala (anticodon CGC) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
high mobility group nucleosome-binding domain-containing protein 4
Names
high mobility group protein N4
high-mobility group (nonhistone chromosomal) protein 17-like 3
high-mobility group protein 17-like 3
non-histone chromosomal protein HMG-17-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006353.3NP_006344.1  high mobility group nucleosome-binding domain-containing protein 4

    See identical proteins and their annotated locations for NP_006344.1

    Status: REVIEWED

    Source sequence(s)
    AL121936
    Consensus CDS
    CCDS4615.1
    UniProtKB/Swiss-Prot
    O00479
    UniProtKB/TrEMBL
    A0A024R046
    Related
    ENSP00000366798.1, ENST00000377575.3
    Conserved Domains (1) summary
    pfam01101
    Location:188
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    26538347..26546933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010172.2XP_016865661.1  high mobility group nucleosome-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    O00479
    UniProtKB/TrEMBL
    A0A024R046
    Conserved Domains (1) summary
    pfam01101
    Location:188
    HMG14_17; HMG14 and HMG17
  2. XM_017010173.2XP_016865662.1  high mobility group nucleosome-binding domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    O00479
    UniProtKB/TrEMBL
    A0A024R046
    Conserved Domains (1) summary
    pfam01101
    Location:188
    HMG14_17; HMG14 and HMG17
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