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PFDN6 prefoldin subunit 6 [ Homo sapiens (human) ]

Gene ID: 10471, updated on 7-Jun-2020

Summary

Official Symbol
PFDN6provided by HGNC
Official Full Name
prefoldin subunit 6provided by HGNC
Primary source
HGNC:HGNC:4926
See related
Ensembl:ENSG00000204220 MIM:605660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKE2; KE-2; PFD6; H2-KE2
Summary
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 26.0), kidney (RPKM 25.3) and 25 other tissues See more
Orthologs

Genomic context

See PFDN6 in Genome Data Viewer
Location:
6p21.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33289597..33290934)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33257374..33258711)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 4 Neighboring gene WD repeat domain 46 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene TAP binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide upregulates gene expression of prefoldin subunit 6 (PFDN6) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prefoldin complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prefoldin subunit 6
Names
HLA class II region expressed gene KE2
KE2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185181.3NP_001172110.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_001172110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AL662820, BE794658, BM686351, CB124036
    Consensus CDS
    CCDS4773.1
    UniProtKB/Swiss-Prot
    O15212
    UniProtKB/TrEMBL
    Q5STK2
    Related
    ENSP00000363734.5, ENST00000374606.9
    Conserved Domains (1) summary
    cd00632
    Location:9113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
  2. NM_001265595.2NP_001252524.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_001252524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BE794658, BM818422
    Consensus CDS
    CCDS4773.1
    UniProtKB/Swiss-Prot
    O15212
    UniProtKB/TrEMBL
    Q5STK2
    Related
    ENSP00000363738.2, ENST00000374610.6
    Conserved Domains (1) summary
    cd00632
    Location:9113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
  3. NM_001265596.1NP_001252525.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_001252525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BE794658, BM745352, DA256816
    Consensus CDS
    CCDS4773.1
    UniProtKB/Swiss-Prot
    O15212
    UniProtKB/TrEMBL
    Q5STK2
    Related
    ENSP00000378563.1, ENST00000395131.5
    Conserved Domains (1) summary
    cd00632
    Location:9113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
  4. NM_014260.3NP_055075.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_055075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BE794658, BM745352, BM792413
    Consensus CDS
    CCDS4773.1
    UniProtKB/Swiss-Prot
    O15212
    UniProtKB/TrEMBL
    Q5STK2
    Related
    ENSP00000363735.1, ENST00000374607.5
    Conserved Domains (1) summary
    cd00632
    Location:9113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33289597..33290934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    4701082..4702419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    4533115..4534452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    4725533..4726870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4484021..4485358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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