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ZNHIT1 zinc finger HIT-type containing 1 [ Homo sapiens (human) ]

Gene ID: 10467, updated on 8-Dec-2022

Summary

Official Symbol
ZNHIT1provided by HGNC
Official Full Name
zinc finger HIT-type containing 1provided by HGNC
Primary source
HGNC:HGNC:21688
See related
Ensembl:ENSG00000106400 MIM:618617; AllianceGenome:HGNC:21688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG1I; ZNFN4A1
Summary
Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 23.5), kidney (RPKM 21.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNHIT1 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101218165..101224190)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102541627..102547653)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100861446..100867471)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 46 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene claudin 15 Neighboring gene fission, mitochondrial 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger HIT domain-containing protein 1
Names
H_DJ0747G18.14
cyclin-G1-binding protein 1
p18 Hamlet
p18Hamlet
putative cyclin G1 interacting protein
zinc finger protein subfamily 4A member 1
zinc finger protein, subfamily 4A (HIT domain containing), member 1
zinc finger, HIT domain containing 1
zinc finger, HIT type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006349.3NP_006340.1  zinc finger HIT domain-containing protein 1

    See identical proteins and their annotated locations for NP_006340.1

    Status: VALIDATED

    Source sequence(s)
    BC001877, BC017333
    Consensus CDS
    CCDS5716.1
    UniProtKB/Swiss-Prot
    O43257, Q6IB12
    Related
    ENSP00000304593.2, ENST00000305105.3
    Conserved Domains (2) summary
    pfam04438
    Location:113140
    zf-HIT; HIT zinc finger
    cl02154
    Location:75135
    YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101218165..101224190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515739.3XP_011514041.1  zinc finger HIT domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam04438
    Location:128155
    zf-HIT; HIT zinc finger
    cl02154
    Location:90150
    YL1_C; YL1 nuclear protein C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102541627..102547653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)