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PPIH peptidylprolyl isomerase H [ Homo sapiens (human) ]

Gene ID: 10465, updated on 6-Jan-2019

Summary

Official Symbol
PPIHprovided by HGNC
Official Full Name
peptidylprolyl isomerase Hprovided by HGNC
Primary source
HGNC:HGNC:14651
See related
Ensembl:ENSG00000171960 MIM:606095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPH; CYP-20; USA-CYP; SnuCyp-20
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See PPIH in Genome Data Viewer
Location:
1p34.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (42657770..42681654)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43123706..43142429)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 30 Neighboring gene TMSB4X pseudogene 1 Neighboring gene RNA, U6 small nuclear 536, pseudogene Neighboring gene Y-box binding protein 1 Neighboring gene claudin 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peptidylprolyl isomerase H (PPIH; cyclophilin H) at amino acid residues 69-70 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystem (from KEGG)
    Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystem (from KEGG)
    Spliceosome, U4/U6.U5 tri-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
positive regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
U4/U6 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
spliceosomal complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase H
Names
PPIase h
U-snRNP-associated cyclophilin SnuCyp-20
U-snRNP-associated cyclophilin SunCyp-20
USA-CyP SnuCyp-20
cyclophilin H
rotamase H
small nuclear ribonucleoprotein particle-specific cyclophilin H
NP_001317439.1
NP_006338.1
XP_005270419.1
XP_005270423.1
XP_016855546.1
XP_016855548.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330510.1NP_001317439.1  peptidyl-prolyl cis-trans isomerase H isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoformn 1.
    Source sequence(s)
    AC098484
    Consensus CDS
    CCDS81308.1
    UniProtKB/Swiss-Prot
    O43447
    Related
    ENSP00000361630.1, ENST00000372550.5
    Conserved Domains (1) summary
    cl00197
    Location:8132
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. NM_006347.4NP_006338.1  peptidyl-prolyl cis-trans isomerase H isoform 1

    See identical proteins and their annotated locations for NP_006338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC003412, BU955702
    Consensus CDS
    CCDS469.1
    UniProtKB/Swiss-Prot
    O43447
    UniProtKB/TrEMBL
    Q6FH36
    Related
    ENSP00000306614.3, ENST00000304979.7
    Conserved Domains (1) summary
    cl00197
    Location:8177
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    42657770..42681654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270366.3XP_005270423.1  peptidyl-prolyl cis-trans isomerase H isoform X2

    See identical proteins and their annotated locations for XP_005270423.1

    Conserved Domains (1) summary
    cl00197
    Location:8146
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. XM_005270362.1XP_005270419.1  peptidyl-prolyl cis-trans isomerase H isoform X1

    See identical proteins and their annotated locations for XP_005270419.1

    UniProtKB/Swiss-Prot
    O43447
    UniProtKB/TrEMBL
    Q6FH36
    Conserved Domains (1) summary
    cl00197
    Location:8177
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  3. XM_017000057.2XP_016855546.1  peptidyl-prolyl cis-trans isomerase H isoform X1

    UniProtKB/Swiss-Prot
    O43447
    UniProtKB/TrEMBL
    Q6FH36
    Conserved Domains (1) summary
    cl00197
    Location:8177
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  4. XM_017000059.2XP_016855548.1  peptidyl-prolyl cis-trans isomerase H isoform X3

    UniProtKB/Swiss-Prot
    O43447
    Conserved Domains (1) summary
    cl00197
    Location:8132
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RNA

  1. XR_946525.1 RNA Sequence

  2. XR_001736914.1 RNA Sequence

  3. XR_001736915.1 RNA Sequence

  4. XR_946524.1 RNA Sequence

  5. XR_946523.1 RNA Sequence

  6. XR_002957847.1 RNA Sequence

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