U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIBF1 progesterone immunomodulatory binding factor 1 [ Homo sapiens (human) ]

Gene ID: 10464, updated on 26-Jan-2024

Summary

Official Symbol
PIBF1provided by HGNC
Official Full Name
progesterone immunomodulatory binding factor 1provided by HGNC
Primary source
HGNC:HGNC:23352
See related
Ensembl:ENSG00000083535 MIM:607532; AllianceGenome:HGNC:23352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIBF; CEP90; JBTS33; C13orf24
Summary
This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 8.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PIBF1 in Genome Data Viewer
Location:
13q21.33-q22.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72782133..73016461)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (72003616..72238006)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73356271..73590599)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:73612066-73612896 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5398 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73648866-73649672 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73649673-73650478 Neighboring gene KLF transcription factor 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Joubert syndrome 33
MedGen: C4540389 OMIM: 617767 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-4 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
progesterone-induced-blocking factor 1
Names
centrosomal protein of 90 kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053118.2 RefSeqGene

    Range
    5002..239330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001349655.2NP_001336584.1  progesterone-induced-blocking factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL354720, AL391384
    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (1) summary
    cl25732
    Location:81721
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_006346.4NP_006337.2  progesterone-induced-blocking factor 1 isoform 2

    See identical proteins and their annotated locations for NP_006337.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL354720, AL391384
    Consensus CDS
    CCDS31991.1
    UniProtKB/Swiss-Prot
    O95664, Q6U9V2, Q6UG50, Q86V07, Q8WXW3, Q96SF4
    UniProtKB/TrEMBL
    A0A087WUI6
    Related
    ENSP00000317144.6, ENST00000326291.11
    Conserved Domains (3) summary
    COG0497
    Location:468698
    RecN; DNA repair ATPase RecN [Replication, recombination and repair]
    TIGR02168
    Location:208538
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RNA

  1. NR_146205.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon compared to variant 1.
    Source sequence(s)
    AL354720, AL391384
  2. NR_146206.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks two exons compared to variant 1.
    Source sequence(s)
    AL354720, AL391384

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    72782133..73016461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534882.4XP_011533184.1  progesterone-induced-blocking factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (2) summary
    TIGR02168
    Location:208567
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. XM_024449314.2XP_024305082.1  progesterone-induced-blocking factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (1) summary
    cl25732
    Location:208538
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_011534885.4XP_011533187.1  progesterone-induced-blocking factor 1 isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:85444
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_047430045.1XP_047286001.1  progesterone-induced-blocking factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WUI6
  5. XM_047430047.1XP_047286003.1  progesterone-induced-blocking factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A087WUI6
    Related
    ENSP00000478697.1, ENST00000617689.4
  6. XM_047430046.1XP_047286002.1  progesterone-induced-blocking factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A087WUI6
  7. XM_047430048.1XP_047286004.1  progesterone-induced-blocking factor 1 isoform X8

    UniProtKB/TrEMBL
    A0A087WUI6
  8. XM_011534884.4XP_011533186.1  progesterone-induced-blocking factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (2) summary
    TIGR02168
    Location:208567
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  9. XM_047430049.1XP_047286005.1  progesterone-induced-blocking factor 1 isoform X9

    UniProtKB/TrEMBL
    A0A087WUI6
  10. XM_017020351.2XP_016875840.1  progesterone-induced-blocking factor 1 isoform X10

  11. XM_011534886.4XP_011533188.1  progesterone-induced-blocking factor 1 isoform X11

    UniProtKB/TrEMBL
    Q05DN0
    Conserved Domains (1) summary
    COG1196
    Location:36357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. XM_047430050.1XP_047286006.1  progesterone-induced-blocking factor 1 isoform X12

    UniProtKB/TrEMBL
    Q05DN0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    72003616..72238006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374017.1XP_054229992.1  progesterone-induced-blocking factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087WUI6
  2. XM_054374019.1XP_054229994.1  progesterone-induced-blocking factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087WUI6
  3. XM_054374021.1XP_054229996.1  progesterone-induced-blocking factor 1 isoform X5

  4. XM_054374018.1XP_054229993.1  progesterone-induced-blocking factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WUI6
  5. XM_054374022.1XP_054229997.1  progesterone-induced-blocking factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A087WUI6
  6. XM_054374020.1XP_054229995.1  progesterone-induced-blocking factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A087WUI6
  7. XM_054374024.1XP_054229999.1  progesterone-induced-blocking factor 1 isoform X8

    UniProtKB/TrEMBL
    A0A087WUI6
  8. XM_054374023.1XP_054229998.1  progesterone-induced-blocking factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087WUI6
  9. XM_054374025.1XP_054230000.1  progesterone-induced-blocking factor 1 isoform X9

    UniProtKB/TrEMBL
    A0A087WUI6
  10. XM_054374026.1XP_054230001.1  progesterone-induced-blocking factor 1 isoform X10

  11. XM_054374028.1XP_054230003.1  progesterone-induced-blocking factor 1 isoform X12

    UniProtKB/TrEMBL
    Q05DN0
  12. XM_054374027.1XP_054230002.1  progesterone-induced-blocking factor 1 isoform X11

    UniProtKB/TrEMBL
    Q05DN0