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TACC3 transforming acidic coiled-coil containing protein 3 [ Homo sapiens (human) ]

Gene ID: 10460, updated on 5-Sep-2021

Summary

Official Symbol
TACC3provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 3provided by HGNC
Primary source
HGNC:HGNC:11524
See related
Ensembl:ENSG00000013810 MIM:605303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERIC1; Tacc4; ERIC-1; maskin
Summary
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Expression
Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues See more
Orthologs
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Genomic context

See TACC3 in Genome Data Viewer
Location:
4p16.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (1721497..1745171)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1723248..1746898)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stem-loop binding protein Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene uncharacterized LOC112268460 Neighboring gene CRISPRi-validated cis-regulatory element chr4.260 Neighboring gene fibroblast growth factor receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
GeneReviews: Not available
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
GeneReviews: Not available
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117382, MGC133242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization involved in mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_064424.1 RefSeqGene

    Range
    5032..28682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1367

mRNA and Protein(s)

  1. NM_006342.3NP_006333.1  transforming acidic coiled-coil-containing protein 3

    See identical proteins and their annotated locations for NP_006333.1

    Status: REVIEWED

    Source sequence(s)
    AF093543, AI684124, DB098941
    Consensus CDS
    CCDS3352.1
    UniProtKB/Swiss-Prot
    Q9Y6A5
    Related
    ENSP00000326550.4, ENST00000313288.9
    Conserved Domains (2) summary
    pfam05010
    Location:639832
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:652753
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    1721497..1745171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247929.3XP_005247986.1  transforming acidic coiled-coil-containing protein 3 isoform X1

    Conserved Domains (2) summary
    pfam05010
    Location:639836
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:656757
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. XM_005247930.3XP_005247987.1  transforming acidic coiled-coil-containing protein 3 isoform X4

    Related
    ENSP00000478580.2, ENST00000612220.5
    Conserved Domains (1) summary
    pfam05010
    Location:279476
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. XM_011513386.3XP_011511688.1  transforming acidic coiled-coil-containing protein 3 isoform X3

    Conserved Domains (2) summary
    PRK12323
    Location:239482
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    pfam05010
    Location:639691
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. XM_017007653.1XP_016863142.1  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y6A5
    Conserved Domains (2) summary
    pfam05010
    Location:639832
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl23765
    Location:652753
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
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