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CDX4 caudal type homeobox 4 [ Homo sapiens (human) ]

Gene ID: 1046, updated on 15-Sep-2020

Summary

Official Symbol
CDX4provided by HGNC
Official Full Name
caudal type homeobox 4provided by HGNC
Primary source
HGNC:HGNC:1808
See related
Ensembl:ENSG00000131264 MIM:300025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CDX4 in Genome Data Viewer
Location:
Xq13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (73447254..73454585)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (72667090..72674421)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 8 Neighboring gene RNA, U6 small nuclear 1044, pseudogene Neighboring gene mortality factor 4 like 1 pseudogene 6 Neighboring gene mitogen-activated protein kinase kinase 4 pseudogene 1 Neighboring gene ribosomal protein L7 pseudogene 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterior/posterior axis specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryo development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein CDX-4
Names
caudal type homeobox transcription factor 4
caudal-type homeobox protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005193.2NP_005184.1  homeobox protein CDX-4

    See identical proteins and their annotated locations for NP_005184.1

    Status: REVIEWED

    Source sequence(s)
    AL450108
    Consensus CDS
    CCDS14424.1
    UniProtKB/Swiss-Prot
    O14627
    Related
    ENSP00000362613.1, ENST00000373514.2
    Conserved Domains (2) summary
    pfam00046
    Location:177229
    Homeobox; Homeobox domain
    pfam04731
    Location:13162
    Caudal_act; Caudal like protein activation region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    73447254..73454585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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