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MHRT myosin heavy chain associated RNA transcript [ Homo sapiens (human) ]

Gene ID: 104564225, updated on 2-Nov-2024

Summary

Official Symbol
MHRTprovided by HGNC
Official Full Name
myosin heavy chain associated RNA transcriptprovided by HGNC
Primary source
HGNC:HGNC:51291
See related
MIM:616096; AllianceGenome:HGNC:51291
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Myheart
Summary
This gene encodes a spliced long non-coding RNA that may act as a cardioprotective agent in the heart. Based on a study of a similar gene in mouse, the encoded transcript may regulate chromatin remodeling by acting as a decoy to the BRG1 chromatin repressor complex thus preventing it from binding to its genomic targets. Blocking the actions of BRG1 could be crucial in protecting the heart from pathological hypertrophy. [provided by RefSeq, Dec 2014]
Expression
Restricted expression toward heart (RPKM 2213.9) See more
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Genomic context

See MHRT in Genome Data Viewer
Location:
14q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23415450..23417595)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17616454..17618599)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23884659..23886804)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8171 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23854904-23856103 Neighboring gene CKLF like MARVEL transmembrane domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858153-23858756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858757-23859360 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 208a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871133-23871675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871676-23872217 Neighboring gene VISTA enhancer hs2155 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23884455-23885654 Neighboring gene myosin heavy chain 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23893609-23894808 Neighboring gene microRNA 208b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23904729-23905566 Neighboring gene VISTA enhancer hs1670 Neighboring gene VISTA enhancer hs2330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5609 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:23938675-23939615 Neighboring gene neuroguidin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein sequestering activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_126491.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132855

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23415450..23417595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17616454..17618599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)