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PPIE peptidylprolyl isomerase E [ Homo sapiens (human) ]

Gene ID: 10450, updated on 3-Jan-2019

Summary

Official Symbol
PPIEprovided by HGNC
Official Full Name
peptidylprolyl isomerase Eprovided by HGNC
Primary source
HGNC:HGNC:9258
See related
Ensembl:ENSG00000084072 MIM:602435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP33; CYP-33
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See PPIE in Genome Data Viewer
Location:
1p34.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (39738845..39765698)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40204517..40229586)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 25 pseudogene Neighboring gene RNA, U7 small nuclear 121 pseudogene Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA-transferase 2 Neighboring gene uncharacterized LOC105378666

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular peptidylprolyl isomerase E protein (PPIE, cyclophilin E) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Dual incision in TC-NER, organism-specific biosystem (from REACTOME)
    Dual incision in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), the oligonucleotide that contains the lesion is excised from the open bubbl...
  • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
    Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
  • Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
    Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fil...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
    Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Spliceosome, 35S U5-snRNP, conserved biosystem (from KEGG)
    Spliceosome, 35S U5-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
    Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3736, MGC111222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity TAS
Traceable Author Statement
more info
PubMed 
poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase E
Names
PPIase E
cyclophilin-33
peptidylprolyl isomerase E (cyclophilin E)
rotamase E
NP_001181936.1
NP_001306222.1
NP_006103.1
NP_982281.1
XP_006710352.1
XP_006710353.1
XP_011538803.1
XP_016855540.1
XP_016855541.1
XP_024306020.1
XP_024306032.1
XP_024306045.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044984.2 RefSeqGene

    Range
    51664..76733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195007.1NP_001181936.1  peptidyl-prolyl cis-trans isomerase E isoform 4

    See identical proteins and their annotated locations for NP_001181936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL049824, BU689929, DA079924, DQ160195
    Consensus CDS
    CCDS53299.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000361918.1, ENST00000372830.5
    Conserved Domains (3) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01926
    Location:140279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  2. NM_001319293.1NP_001306222.1  peptidyl-prolyl cis-trans isomerase E isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CA445146, CT002466, DA079924
    Conserved Domains (3) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01926
    Location:129268
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  3. NM_006112.3NP_006103.1  peptidyl-prolyl cis-trans isomerase E isoform 1

    See identical proteins and their annotated locations for NP_006103.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AL049824, BC004898, CK300365, DA079924
    Consensus CDS
    CCDS443.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000312769.5, ENST00000324379.9
    Conserved Domains (2) summary
    cd01926
    Location:140298
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  4. NM_203456.2NP_982281.1  peptidyl-prolyl cis-trans isomerase E isoform 2

    See identical proteins and their annotated locations for NP_982281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon and thereby differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AF042386, BU689929, DA079924
    Consensus CDS
    CCDS442.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000348904.2, ENST00000356511.6
    Conserved Domains (3) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01926
    Location:140281
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

RNA

  1. NR_036543.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-most exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL049824, BU160972, CK300365, DA079924
  2. NR_036544.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites in the 5'-most exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK304694, AL049824, CK300365, DA079924

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    39738845..39765698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450277.1XP_024306045.1  peptidyl-prolyl cis-trans isomerase E isoform X6

    Conserved Domains (1) summary
    cd01926
    Location:56197
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
  2. XM_011540501.1XP_011538803.1  peptidyl-prolyl cis-trans isomerase E isoform X4

    Conserved Domains (1) summary
    cl00197
    Location:56195
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  3. XM_017000052.1XP_016855541.1  peptidyl-prolyl cis-trans isomerase E isoform X5

    UniProtKB/TrEMBL
    B3KSZ1
    Conserved Domains (1) summary
    cd01926
    Location:56214
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
  4. XM_006710289.3XP_006710352.1  peptidyl-prolyl cis-trans isomerase E isoform X2

    Conserved Domains (3) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    cl00197
    Location:129266
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  5. XM_006710290.4XP_006710353.1  peptidyl-prolyl cis-trans isomerase E isoform X3

    See identical proteins and their annotated locations for XP_006710353.1

    Conserved Domains (2) summary
    cd01926
    Location:129285
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  6. XM_017000051.2XP_016855540.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    UniProtKB/Swiss-Prot
    Q9UNP9
    Conserved Domains (3) summary
    COG0724
    Location:584
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01926
    Location:140279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  7. XM_024450264.1XP_024306032.1  peptidyl-prolyl cis-trans isomerase E isoform X5

    Related
    ENSP00000433475.1, ENST00000497370.5
    Conserved Domains (1) summary
    cd01926
    Location:56214
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
  8. XM_024450252.1XP_024306020.1  peptidyl-prolyl cis-trans isomerase E isoform X4

    Conserved Domains (1) summary
    cl00197
    Location:56195
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RNA

  1. XR_946521.3 RNA Sequence

  2. XR_946520.3 RNA Sequence

  3. XR_946519.3 RNA Sequence

    Related
    ENST00000475350.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203457.1: Suppressed sequence

    Description
    NM_203457.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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