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MCRS1 microspherule protein 1 [ Homo sapiens (human) ]

Gene ID: 10445, updated on 4-Dec-2022

Summary

Official Symbol
MCRS1provided by HGNC
Official Full Name
microspherule protein 1provided by HGNC
Primary source
HGNC:HGNC:6960
See related
Ensembl:ENSG00000187778 MIM:609504; AllianceGenome:HGNC:6960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P78; MCRS2; MSP58; INO80Q; ICP22BP
Summary
Enables RNA binding activity and telomerase inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See MCRS1 in Genome Data Viewer
Location:
12q13.12
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49558299..49568142, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49520555..49530398, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49952082..49961925, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated serine rich 2 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene uncharacterized LOC105369761 Neighboring gene potassium voltage-gated channel subfamily H member 3 Neighboring gene family with sequence similarity 186 member B Neighboring gene RNA, U6 small nuclear 834, pseudogene Neighboring gene RNA polymerase II subunit K pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41193, FLJ98622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-quadruplex RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(G) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA repair IC
Inferred by Curator
more info
 
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomere maintenance in response to DNA damage IC
Inferred by Curator
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein modification process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair IC
Inferred by Curator
more info
 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dosage compensation by inactivation of X chromosome IC
Inferred by Curator
more info
 
involved_in regulation of embryonic development IC
Inferred by Curator
more info
 
involved_in telomere maintenance IC
Inferred by Curator
more info
 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of polysome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
microspherule protein 1
Names
58 kDa microspherule protein
INO80 complex subunit J
INO80 complex subunit Q
cell cycle-regulated factor (78 kDa)
cell cycle-regulated factor p78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012300.1NP_001012300.1  microspherule protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001012300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AY336730, BC011794
    Consensus CDS
    CCDS31795.1
    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENSP00000349640.4, ENST00000357123.8
    Conserved Domains (2) summary
    cd00060
    Location:358458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147344
    MCRS_N; N-terminal region of micro-spherule protein
  2. NM_001278341.2NP_001265270.1  microspherule protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001265270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 2. The resulting isoform (3) has a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, BX538079, HY078747, R66413
    Consensus CDS
    CCDS61118.1
    UniProtKB/Swiss-Prot
    Q96EZ8
    UniProtKB/TrEMBL
    A0A024R134
    Related
    ENSP00000444982.1, ENST00000546244.5
    Conserved Domains (2) summary
    cd00060
    Location:154254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:1140
    MCRS_N; N-terminal region of micro-spherule protein
  3. NM_006337.5NP_006328.2  microspherule protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006328.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' coding sequence, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, HY078747, R66413
    Consensus CDS
    CCDS8787.1
    UniProtKB/Swiss-Prot
    Q7Z372, Q96EZ8
    Related
    ENSP00000345358.4, ENST00000343810.9
    Conserved Domains (2) summary
    cd00060
    Location:345445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134331
    MCRS_N; N-terminal region of micro-spherule protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49558299..49568142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537760.4XP_011536062.2  microspherule protein 1 isoform X1

  2. XM_005268572.3XP_005268629.1  microspherule protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005268629.1

    UniProtKB/Swiss-Prot
    Q7Z372, Q96EZ8
    Related
    ENSP00000448056.1, ENST00000550165.5
    Conserved Domains (2) summary
    cd00060
    Location:345445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134331
    MCRS_N; N-terminal region of micro-spherule protein
  3. XM_017018690.2XP_016874179.1  microspherule protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENST00000551625.5
    Conserved Domains (2) summary
    cd00060
    Location:358458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147344
    MCRS_N; N-terminal region of micro-spherule protein
  4. XM_047428083.1XP_047284039.1  microspherule protein 1 isoform X4

    Related
    ENSP00000447514.1, ENST00000553173.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49520555..49530398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)