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Rexo2 RNA exonuclease 2 [ Mus musculus (house mouse) ]

Gene ID: 104444, updated on 5-Jan-2023

Summary

Official Symbol
Rexo2provided by MGI
Official Full Name
RNA exonuclease 2provided by MGI
Primary source
MGI:MGI:1888981
See related
Ensembl:ENSMUSG00000032026 AllianceGenome:MGI:1888981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfn; Rex2; Smfn; 1810038D15Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 86.0), liver E14 (RPKM 25.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rexo2 in Genome Data Viewer
Location:
9; 9 A5.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48379812..48391911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48468512..48480611, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene 8884 Neighboring gene predicted gene, 39334 Neighboring gene RNA binding motif protein 7 Neighboring gene predicted gene 5617

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables 3'-5'-DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within nucleobase-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oligoribonuclease, mitochondrial
Names
REX2, RNA exonuclease 2 homolog
small fragment nuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357501.2NP_001344430.1  oligoribonuclease, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC160992
    Conserved Domains (1) summary
    cd06135
    Location:46187
    Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
  2. NM_001357503.1NP_001344432.1  oligoribonuclease, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AC160992
    Consensus CDS
    CCDS90558.1
    UniProtKB/TrEMBL
    A0A1L1SS70, A0A8C6H1F9
    Related
    ENSMUSP00000149784.2, ENSMUST00000217037.2
    Conserved Domains (1) summary
    cl10012
    Location:39121
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  3. NM_001357505.1NP_001344434.1  oligoribonuclease, mitochondrial isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC160992
    Consensus CDS
    CCDS90557.1
    UniProtKB/TrEMBL
    A0A1L1SQJ5, A0A8C6H3B1
    Related
    ENSMUSP00000149074.2, ENSMUST00000216470.2
    Conserved Domains (1) summary
    cl10012
    Location:39103
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  4. NM_024233.4NP_077195.2  oligoribonuclease, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_077195.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI839882, AK007731
    Consensus CDS
    CCDS23154.1
    UniProtKB/Swiss-Prot
    Q9D8S4
    UniProtKB/TrEMBL
    A0A8C6H1E1
    Related
    ENSMUSP00000034524.4, ENSMUST00000034524.5
    Conserved Domains (1) summary
    cd06135
    Location:43215
    Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    48379812..48391911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)