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ZER1 zyg-11 related cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 10444, updated on 6-Sep-2021

Summary

Official Symbol
ZER1provided by HGNC
Official Full Name
zyg-11 related cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:30960
See related
Ensembl:ENSG00000160445 MIM:617764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZYG; C9orf60; ZYG11BL
Summary
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in brain (RPKM 20.9), testis (RPKM 20.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZER1 in Genome Data Viewer
Location:
9q34.11
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128729786..128772486, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131492065..131534765, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 560, pseudogene Neighboring gene protein kinase N3 Neighboring gene ZDHHC12 divergent transcript Neighboring gene zinc finger DHHC-type palmitoyltransferase 12 Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033 Neighboring gene TBC1 domain family member 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • RP11-545E17.4

General protein information

Preferred Names
protein zer-1 homolog
Names
ZYG homolog
zer-1 homolog
zyg-11 homolog B-like protein
zyg11b-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375954.1NP_001362883.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562600
    ARM; armadillo repeat [structural motif]
  2. NM_001375955.1NP_001362884.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562600
    ARM; armadillo repeat [structural motif]
  3. NM_001375956.1NP_001362885.1  protein zer-1 homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562600
    ARM; armadillo repeat [structural motif]
  4. NM_001375957.1NP_001362886.1  protein zer-1 homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560598
    ARM; armadillo repeat [structural motif]
  5. NM_001375958.1NP_001362887.1  protein zer-1 homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560598
    ARM; armadillo repeat [structural motif]
  6. NM_001375959.1NP_001362888.1  protein zer-1 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Conserved Domains (2) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
  7. NM_006336.4NP_006327.2  protein zer-1 homolog isoform 1

    See identical proteins and their annotated locations for NP_006327.2

    Status: REVIEWED

    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    Q7Z7L7
    UniProtKB/TrEMBL
    A0A024R8B0
    Related
    ENSP00000291900.2, ENST00000291900.7
    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562600
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128729786..128772486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014188.1XP_016869677.1  protein zer-1 homolog isoform X2

    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560598
    ARM; armadillo repeat [structural motif]
  2. XM_017014189.2XP_016869678.1  protein zer-1 homolog isoform X3

    Conserved Domains (2) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_017014187.2XP_016869676.1  protein zer-1 homolog isoform X2

    Conserved Domains (3) summary
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560598
    ARM; armadillo repeat [structural motif]
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